Constitutive Signaling by NOTCH1 PEST Domain Mutants

Q: What compounds affect the Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway?

94 compounds in the BiohacksAI corpus have documented interactions with genes in the Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway (Reactome ID: R-HSA-2644606). These compounds target 30 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-264460630 genes94 compounds

The Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway (Reactome ID: R-HSA-2644606) involves 30 genes and is affected by 94 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 APH1A APH1B CCNC CDK8 CREBBP CUL1 EP300 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 KAT2A KAT2B MYC NCOR1 NCOR2 NCSTN PSEN1 PSEN2 PSENEN RBX1

Compounds Affecting Constitutive Signaling by NOTCH1 PEST Domain Mutants

#	Compound	Targets Hit	Studies
1	Vorinostat	—	299
2	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
3	scriptaid	—	53
4	pictilisib	—	25
5	Valproic Acid	—	296
6	Butyric Acid	—	300
7	Ursolic Acid	—	300
8	Camptothecin	—	300
9	Celecoxib	—	295
10	Daunorubicin	—	298
11	Chlorogenic Acid	—	300
12	gamma-Aminobutyric Acid	—	300
13	Dihydroergocristine	—	187
14	Kaempferols	—	300
15	Bortezomib	—	300
16	Genistein	—	300
17	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
18	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
19	Pueraria	—	300
20	Quercetin	—	300
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	chrysin	—	300
23	Axitinib	—	298
24	Febuxostat	—	297
25	Nocodazole Nocodazole is	—	215
26	Iodoacetamide	—	300
27	Bufexamac	—	137
28	candesartan cilexetil [Supplementary Concept]	—	300
29	Hexachlorophene	—	300
30	Bisphenol A-Glycidyl Methacrylate	—	197
31	Sorafenib	—	300
32	plumbagin [Supplementary Concept]	—	300
33	egcg	—	300
34	ninhydrin	—	300
35	Resveratrol	—	298
36	Carboxin	—	174
37	Leflunomide	—	297
38	Linuron	—	299
39	Niclosamide	—	299
40	Methylene Blue	—	200
41	amlexanox	—	96
42	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
43	2-Acetylaminofluorene	—	300
44	diethylhydroxylamine	—	21
45	felbinac	—	31
46	Gemfibrozil	—	297
47	Niflumic Acid	—	300
48	Oxyphenbutazone	—	300
49	Riluzole	—	298
50	thiophanate	—	300

About the Constitutive Signaling by NOTCH1 PEST Domain Mutants Pathway

The Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway is catalogued in Reactome (ID: R-HSA-2644606) and involves 30 genes. In the BiohacksAI corpus, 94 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, APH1A, APH1B, CCNC.