What compounds affect the Transcriptional Regulation by TP53 pathway?

323 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional Regulation by TP53 pathway (Reactome ID: R-HSA-3700989). These compounds target 85 genes within this pathway.

What genes are in the Transcriptional Regulation by TP53 pathway?

The Transcriptional Regulation by TP53 pathway involves 85 genes. Key genes include: AGO2, AKT3, ATM, AURKA, AURKB, BARD1, BIRC5, BLM, BRCA1, CARM1.

Transcriptional Regulation by TP53

REACTOME PATHWAY

Reactome: R-HSA-370098985 genes323 compounds

The Transcriptional Regulation by TP53 pathway (Reactome ID: R-HSA-3700989) involves 85 genes and is affected by 323 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AKT3 ATM AURKA AURKB BARD1 BIRC5 BLM BRCA1 CARM1 CASP1 CASP2 CCNA1 CCNB1 CCNE2 CCNT2 CDK1 CDK13 CDK2 CDK5 CDK5R1 CDK7 CDK9 CHEK1 CHEK2 COX1 COX2 CREBBP CSNK2A1 CSNK2A2+55 more

Compounds Affecting Transcriptional Regulation by TP53

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	kenpaullone	—	8
3	Niclosamide	—	299
4	Rotenone	—	300
5	Quercetin	—	300
6	Ursolic Acid	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	alsterpaullone	—	12
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Disulfiram	—	297
12	Sorafenib	—	300
13	fisetin	—	78
14	chrysin	—	300
15	Antimycin	—	300
16	egcg	—	300
17	pictilisib	—	25
18	Oleanolic Acid	—	300
19	Methylene Blue	—	200
20	Nocodazole Nocodazole is	—	215
21	Colchicine	—	300
22	Calcimycin	—	216
23	Adenosine Monophosphate Adenine nucleotide containing	—	300
24	Proguanil	—	299
25	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
26	Berberine	—	300
27	Metformin	—	1,000
28	Hexachlorophene	—	300
29	vinblastine sulfate	—	81
30	rafoxanide	—	172
31	Ku 0063794 [Supplementary Concept]	—	7
32	ly294002	—	11
33	Kaempferols	—	300
34	hydroxyfasudil [Supplementary Concept]	—	11
35	s adenosylhomocysteine	—	300
36	Azacitidine	—	298
37	Azacitidine	—	300
38	Cytarabine	—	297
39	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
40	Melphalan	—	300
41	Methotrexate	—	289
42	Trifluridine	—	295
43	Ciclopirox	—	88
44	cycloheximide	—	300
45	Vorinostat	—	299
46	Thioridazine	—	35
47	Nisoldipine	—	297
48	Sertraline	—	1,000
49	Astemizole Antihistamine drug now withdrawn from	—	280
50	Chlorhexidine	—	299

About the Transcriptional Regulation by TP53 Pathway

The Transcriptional Regulation by TP53 pathway is catalogued in Reactome (ID: R-HSA-3700989) and involves 85 genes. In the BiohacksAI corpus, 323 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AKT3, ATM, AURKA, AURKB.