What compounds affect the Axon guidance pathway?

249 compounds in the BiohacksAI corpus have documented interactions with genes in the Axon guidance pathway (Reactome ID: R-HSA-422475). These compounds target 151 genes within this pathway.

What genes are in the Axon guidance pathway?

The Axon guidance pathway involves 151 genes. Key genes include: ABL1, ABL2, ADAM10, ADRM1, APH1A, APH1B, ARHGAP35, BUB1B-PAK6, CACNA1C, CACNA1D.

Axon guidance

REACTOME PATHWAY

Reactome: R-HSA-422475151 genes249 compounds

The Axon guidance pathway (Reactome ID: R-HSA-422475) involves 151 genes and is affected by 249 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 ADAM10 ADRM1 APH1A APH1B ARHGAP35 BUB1B-PAK6 CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CDC42 CDK5 CDK5R1 CFL1 CREB1 CSNK2A1 CSNK2A2 CSNK2B DPYSL2 EGFR EIF4G1 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5+121 more

Compounds Affecting Axon guidance

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Crizotinib	—	298
5	Nocodazole Nocodazole is	—	215
6	Reserpine	—	297
7	Colchicine	—	300
8	kenpaullone	—	8
9	sp600125	—	117
10	Vincristine	—	299
11	Noscapine	—	300
12	Quercetin	—	300
13	Podophyllotoxin	—	14
14	Demecolcine	—	246
15	Maytansine	—	300
16	vinblastine sulfate	—	81
17	Vorinostat	—	299
18	alsterpaullone	—	12
19	Axitinib	—	298
20	tyrphostin ag 1478	—	4
21	fisetin	—	78
22	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
23	pictilisib	—	25
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	chrysin	—	300
26	Hexachlorophene	—	300
27	Saxitoxin	—	300
28	Afatinib	—	297
29	Kaempferols	—	300
30	ly294002	—	11
31	egcg	—	300
32	hydroxyfasudil [Supplementary Concept]	—	11
33	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
34	Quinidine	—	298
35	Veratridine	—	300
36	Flunarizine Flunarizine is	—	299
37	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
38	Dihydroergocristine	—	187
39	Genistein	—	300
40	Nisoldipine	—	297
41	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
42	Duloxetine Hydrochloride	—	993
43	Astemizole Antihistamine drug now withdrawn from	—	280
44	alpelisib	—	227
45	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
46	Sirolimus	—	300
47	Ethidium	—	300
48	Clotrimazole	—	296
49	Wortmannin	—	300
50	Bupivacaine	—	300

About the Axon guidance Pathway

The Axon guidance pathway is catalogued in Reactome (ID: R-HSA-422475) and involves 151 genes. In the BiohacksAI corpus, 249 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, ADAM10, ADRM1, APH1A.