What compounds affect the Signaling by Hedgehog pathway?

246 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Hedgehog pathway (Reactome ID: R-HSA-5358351). These compounds target 60 genes within this pathway.

What genes are in the Signaling by Hedgehog pathway?

The Signaling by Hedgehog pathway involves 60 genes. Key genes include: ADAM17, ADCY9, ADRM1, ARRB1, CSNK1A1, CUL1, GLI3, GNAS, GRK2, GSK3B.

Signaling by Hedgehog

REACTOME PATHWAY

Reactome: R-HSA-535835160 genes246 compounds

The Signaling by Hedgehog pathway (Reactome ID: R-HSA-5358351) involves 60 genes and is affected by 246 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 ADCY9 ADRM1 ARRB1 CSNK1A1 CUL1 GLI3 GNAS GRK2 GSK3B P4HB PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2+30 more

Compounds Affecting Signaling by Hedgehog

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Colchicine	—	300
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Nocodazole Nocodazole is	—	215
7	Vincristine	—	299
8	Demecolcine	—	246
9	Maytansine	—	300
10	Noscapine	—	300
11	Vorinostat	—	299
12	egcg	—	300
13	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
14	Disulfiram	—	297
15	Kaempferols	—	300
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	chrysin	—	300
18	ninhydrin	—	300
19	sp600125	—	117
20	hydroxyfasudil [Supplementary Concept]	—	11
21	Hexachlorophene	—	300
22	Genistein	—	300
23	Methylene Blue	—	200
24	Vitamin	—	295
25	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
26	Cilostazol	—	297
27	Equilin	—	216
28	Prednisolone	—	1,000
29	Bisphenol A-Glycidyl Methacrylate	—	197
30	candesartan cilexetil [Supplementary Concept]	—	300
31	Carmustine	—	297
32	Clotrimazole	—	296
33	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
34	Nicardipine	—	94
35	Niclosamide	—	299
36	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
37	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
38	Quercetin	—	300
39	Sorafenib	—	300
40	Edaravone	—	298
41	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
42	Aurintricarboxylic Acid	—	184
43	Corticosterone	—	300
44	Estrone	—	300
45	Carbaryl	—	300
46	cycloheximide	—	300
47	Pueraria	—	300
48	Dehydroepiandrosterone	—	300
49	Progesterone	—	299
50	Androstenedione	—	300

About the Signaling by Hedgehog Pathway

The Signaling by Hedgehog pathway is catalogued in Reactome (ID: R-HSA-5358351) and involves 60 genes. In the BiohacksAI corpus, 246 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, ADCY9, ADRM1, ARRB1, CSNK1A1.