What compounds affect the Metabolism of lipids pathway?

817 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of lipids pathway (Reactome ID: R-HSA-556833). These compounds target 153 genes within this pathway.

What genes are in the Metabolism of lipids pathway?

The Metabolism of lipids pathway involves 153 genes. Key genes include: ABCB11, ABCC1, ABCC3, ABCG2, ACAD11, ACHE, AHR, AKR1C1, AKR1C2, AKR1C3.

Metabolism of lipids

REACTOME PATHWAY

Reactome: R-HSA-556833153 genes817 compounds

The Metabolism of lipids pathway (Reactome ID: R-HSA-556833) involves 153 genes and is affected by 817 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCC1 ABCC3 ABCG2 ACAD11 ACHE AHR AKR1C1 AKR1C2 AKR1C3 AKR1C4 ALB ALOX12 ALOX15 ALOX15B ALOX5 ARNT ARSA BCHE BDH2 BMX CARM1 CBR1 CCNC CDK19 CDK8 CPT2 CREBBP CSNK1G2 CSNK2A1+123 more

Compounds Affecting Metabolism of lipids

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Kaempferols	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Disulfiram	—	297
6	chrysin	—	300
7	Hexachlorophene	—	300
8	Clotrimazole	—	296
9	Chlorhexidine	—	299
10	Genistein	—	300
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	Ethidium	—	300
13	Rotenone	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Progesterone	—	299
16	Methylene Blue	—	200
17	Gemfibrozil	—	297
18	Miconazole	—	298
19	Linoleic Acid	—	300
20	Reserpine	—	297
21	ly294002	—	11
22	Daunorubicin	—	298
23	Troglitazone	—	299
24	Masoprocol	—	300
25	Arachidonic Acid	—	245
26	pictilisib	—	25
27	Ethoxyquin Antioxidant; also	—	180
28	Vitamin K 3	—	300
29	Celecoxib	—	295
30	Astemizole Antihistamine drug now withdrawn from	—	280
31	Edaravone	—	298
32	Simvastatin	—	1,000
33	Triiodothyronine	—	300
34	Berberine	—	300
35	Niclosamide	—	299
36	candesartan cilexetil [Supplementary Concept]	—	300
37	Thyroxine	—	994
38	Thyroxine	—	300
39	Fenofibrate	—	297
40	Nisoldipine	—	297
41	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
42	cbd	—	298
43	cannabidiol	—	296
44	Iodoacetamide	—	300
45	Mometasone Furoate	—	292
46	Retinaldehyde	—	300
47	Ritonavir	—	298
48	Methotrexate	—	289
49	Sirolimus	—	300
50	Ethinyl Estradiol	—	300

About the Metabolism of lipids Pathway

The Metabolism of lipids pathway is catalogued in Reactome (ID: R-HSA-556833) and involves 153 genes. In the BiohacksAI corpus, 817 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCC1, ABCC3, ABCG2, ACAD11.