Metabolic disorders of biological oxidation enzymes

Q: What compounds affect the Metabolic disorders of biological oxidation enzymes pathway?

149 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolic disorders of biological oxidation enzymes pathway (Reactome ID: R-HSA-5579029). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-557902911 genes149 compounds

The Metabolic disorders of biological oxidation enzymes pathway (Reactome ID: R-HSA-5579029) involves 11 genes and is affected by 149 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHCY CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1B1 CYP24A1 MAOA TBXAS1 UGT1A1 UGT1A4

Compounds Affecting Metabolic disorders of biological oxidation enzymes

#	Compound	Targets Hit	Studies
1	Letrozole	—	298
2	Fadrozole	—	300
3	chrysin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Quercetin	—	300
9	Anastrozole	—	298
10	Kaempferols	—	300
11	Clotrimazole	—	296
12	Methylene Blue	—	200
13	Miconazole	—	298
14	Kaempferols	—	300
15	Idazoxan	—	300
16	Lynestrenol	—	299
17	Vitamin K 3	—	300
18	Sorafenib	—	300
19	plumbagin [Supplementary Concept]	—	300
20	scutellarein	—	113
21	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
22	Androstenedione	—	300
23	Testosterone	—	299
24	Bortezomib	—	300
25	cycloheximide	—	300
26	Ethidium	—	300
27	Fulvestrant	—	295
28	Lovastatin	—	300
29	Reserpine	—	297
30	Spironolactone	—	298
31	Vitamin	—	295
32	Dactinomycin	—	297
33	Dihydrotestosterone	—	300
34	Disulfiram	—	297
35	Hexachlorophene	—	300
36	mg624	—	3
37	Ouabain	—	300
38	Rotenone	—	300
39	stx64	—	2
40	Acetaldehyde	—	300
41	Amoxapine	—	259
42	Astemizole Antihistamine drug now withdrawn from	—	280
43	Azacitidine	—	298
44	Azacitidine	—	300
45	Celecoxib	—	295
46	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
47	Chlorhexidine	—	299
48	Daunorubicin	—	298
49	Digoxin	—	299
50	Dinitrochlorobenzene	—	300

About the Metabolic disorders of biological oxidation enzymes Pathway

The Metabolic disorders of biological oxidation enzymes pathway is catalogued in Reactome (ID: R-HSA-5579029) and involves 11 genes. In the BiohacksAI corpus, 149 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHCY, CYP11B1, CYP11B2, CYP17A1, CYP19A1.