What compounds affect the Hedgehog 'off' state pathway?

233 compounds in the BiohacksAI corpus have documented interactions with genes in the Hedgehog 'off' state pathway (Reactome ID: R-HSA-5610787). These compounds target 54 genes within this pathway.

What genes are in the Hedgehog 'off' state pathway?

The Hedgehog 'off' state pathway involves 54 genes. Key genes include: ADCY9, ADRM1, CSNK1A1, CUL1, GLI3, GNAS, GSK3B, PRKACA, PRKACB, PRKACG.

Hedgehog 'off' state

REACTOME PATHWAY

Reactome: R-HSA-561078754 genes233 compounds

The Hedgehog 'off' state pathway (Reactome ID: R-HSA-5610787) involves 54 genes and is affected by 233 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADRM1 CSNK1A1 CUL1 GLI3 GNAS GSK3B PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+24 more

Compounds Affecting Hedgehog 'off' state

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Colchicine	—	300
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Nocodazole Nocodazole is	—	215
7	Vincristine	—	299
8	Demecolcine	—	246
9	Maytansine	—	300
10	Noscapine	—	300
11	Vorinostat	—	299
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Disulfiram	—	297
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	chrysin	—	300
16	egcg	—	300
17	ninhydrin	—	300
18	hydroxyfasudil [Supplementary Concept]	—	11
19	Genistein	—	300
20	Kaempferols	—	300
21	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
22	Cilostazol	—	297
23	candesartan cilexetil [Supplementary Concept]	—	300
24	Carmustine	—	297
25	Niclosamide	—	299
26	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
27	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
28	Quercetin	—	300
29	Sorafenib	—	300
30	sp600125	—	117
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
32	Corticosterone	—	300
33	Estrone	—	300
34	Carbaryl	—	300
35	cycloheximide	—	300
36	Hexachlorophene	—	300
37	Pueraria	—	300
38	Dehydroepiandrosterone	—	300
39	Methylene Blue	—	200
40	Progesterone	—	299
41	Androstenedione	—	300
42	Chlorhexidine	—	299
43	Danazol	—	298
44	Dehydroepiandrosterone	—	300
45	Dihydrotestosterone	—	300
46	Estriol	—	300
47	Ethinyl Estradiol	—	300
48	Flutamide	—	298
49	Levonorgestrel	—	292
50	Norethindrone	—	300

About the Hedgehog 'off' state Pathway

The Hedgehog 'off' state pathway is catalogued in Reactome (ID: R-HSA-5610787) and involves 54 genes. In the BiohacksAI corpus, 233 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADRM1, CSNK1A1, CUL1, GLI3.