What compounds affect the ABC transporter disorders pathway?

146 compounds in the BiohacksAI corpus have documented interactions with genes in the ABC transporter disorders pathway (Reactome ID: R-HSA-5619084). These compounds target 39 genes within this pathway.

What genes are in the ABC transporter disorders pathway?

The ABC transporter disorders pathway involves 39 genes. Key genes include: ABCB11, ABCB6, ABCC2, ABCC8, ABCC9, ADRM1, CFTR, PSMA1, PSMA2, PSMA3.

ABC transporter disorders

REACTOME PATHWAY

Reactome: R-HSA-561908439 genes146 compounds

The ABC transporter disorders pathway (Reactome ID: R-HSA-5619084) involves 39 genes and is affected by 146 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCB6 ABCC2 ABCC8 ABCC9 ADRM1 CFTR PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+9 more

Compounds Affecting ABC transporter disorders

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Glyburide	—	298
4	Disulfiram	—	297
5	Pioglitazone	—	297
6	Genistein	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Bumetanide	—	299
10	Nisoldipine	—	297
11	Halcinonide	—	88
12	Hexachlorophene	—	300
13	Mometasone Furoate	—	292
14	Troglitazone	—	299
15	Irbesartan	—	298
16	Clotrimazole	—	296
17	Fusidic Acid	—	300
18	Olmesartan Medoxomil	—	300
19	Rimonabant	—	300
20	egcg	—	300
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	Cromakalim	—	300
23	Anisomycin	—	247
24	cycloheximide	—	300
25	kenpaullone	—	8
26	Vorinostat	—	299
27	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
28	Hydrocortisone	—	299
29	Betamethasone	—	299
30	Chlorthalidone	—	299
31	Ethidium	—	300
32	Hydrocortisone	—	298
33	Cervugid [Supplementary Concept]	—	300
34	Medroxyprogesterone Acetate	—	299
35	Vitamin K 3	—	300
36	Mestranol	—	300
37	Quinestrol	—	194
38	Budesonide	—	1,000
39	Methylene Blue	—	200
40	Prednisolone	—	1,000
41	6-Aminonicotinamide	—	300
42	alsterpaullone	—	12
43	Hyoscyamine	—	296
44	Beclomethasone	—	300
45	Carbazilquinone	—	48
46	Carbidopa	—	298
47	cardamonin	—	180
48	Desoximetasone	—	86
49	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
50	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300

About the ABC transporter disorders Pathway

The ABC transporter disorders pathway is catalogued in Reactome (ID: R-HSA-5619084) and involves 39 genes. In the BiohacksAI corpus, 146 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCB6, ABCC2, ABCC8, ABCC9.