What genes are in the Disorders of transmembrane transporters pathway?

The Disorders of transmembrane transporters pathway involves 65 genes. Key genes include: ABCB11, ABCB6, ABCC2, ABCC8, ABCC9, ADRM1, AVPR1A, AVPR1B, AVPR2, CFTR.

Disorders of transmembrane transporters

Q: What compounds affect the Disorders of transmembrane transporters pathway?

275 compounds in the BiohacksAI corpus have documented interactions with genes in the Disorders of transmembrane transporters pathway (Reactome ID: R-HSA-5619115). These compounds target 65 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-561911565 genes275 compounds

The Disorders of transmembrane transporters pathway (Reactome ID: R-HSA-5619115) involves 65 genes and is affected by 275 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB11 ABCB6 ABCC2 ABCC8 ABCC9 ADRM1 AVPR1A AVPR1B AVPR2 CFTR GCK GCKR PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4+35 more

Compounds Affecting Disorders of transmembrane transporters

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Glyburide	—	298
4	Hexachlorophene	—	300
5	Genistein	—	300
6	Simvastatin	—	1,000
7	Astemizole Antihistamine drug now withdrawn from	—	280
8	Troglitazone	—	299
9	Mometasone Furoate	—	292
10	Ritonavir	—	298
11	Olmesartan Medoxomil	—	300
12	Sertraline	—	1,000
13	Digoxin	—	299
14	Aripiprazole	—	298
15	Ethinyl Estradiol	—	300
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
17	Canagliflozin	—	295
18	Chlorhexidine	—	299
19	Crizotinib	—	298
20	Flunarizine Flunarizine is	—	299
21	Metergoline	—	144
22	Bumetanide	—	299
23	Disulfiram	—	297
24	Pioglitazone	—	297
25	Taurocholic Acid	—	300
26	Rifamycins	—	300
27	Rifamycins	—	300
28	Losartan	—	1,000
29	Clotrimazole	—	296
30	beta Carotene	—	299
31	Antimycin	—	300
32	Gemfibrozil	—	297
33	Quercetin	—	300
34	Arginine Vasopressin	—	298
35	Oxytocin	—	299
36	Deamino Arginine Vasopressin	—	46
37	Ornipressin	—	82
38	Lypressin	—	24
39	Duloxetine Hydrochloride	—	993
40	Fluoxetine	—	1,000
41	Venlafaxine Hydrochloride	—	1,000
42	Amlodipine	—	1,000
43	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
44	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
45	Cabergoline	—	299
46	Amoxapine	—	259
47	Axitinib	—	298
48	Benzydamine	—	298
49	Carvedilol	—	296
50	Caspofungin	—	299

About the Disorders of transmembrane transporters Pathway

The Disorders of transmembrane transporters pathway is catalogued in Reactome (ID: R-HSA-5619115) and involves 65 genes. In the BiohacksAI corpus, 275 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB11, ABCB6, ABCC2, ABCC8, ABCC9.