Diseases of signal transduction by growth factor receptors and second messengers

Q: What compounds affect the Diseases of signal transduction by growth factor receptors and second messengers pathway?

503 compounds in the BiohacksAI corpus have documented interactions with genes in the Diseases of signal transduction by growth factor receptors and second messengers pathway (Reactome ID: R-HSA-5663202). These compounds target 170 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-5663202170 genes503 compounds

The Diseases of signal transduction by growth factor receptors and second messengers pathway (Reactome ID: R-HSA-5663202) involves 170 genes and is affected by 503 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 ADAM17 ADRM1 AGO2 AKT3 ALK APH1A APH1B ARAF ARRB1 ATIC BAD BCL2A1 BCL2L1 BCL2L11 BCR BRAF CAMK2B CAMK2D CASP9 CCNB1 CCNC CDC37 CDK8 CHUK CREB1 CREBBP CSK CSNK1A1 CTBP1+140 more

Compounds Affecting Diseases of signal transduction by growth factor receptors and second messengers

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	sp600125	—	117
5	Quercetin	—	300
6	pictilisib	—	25
7	Axitinib	—	298
8	Crizotinib	—	298
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Daunorubicin	—	298
11	Reserpine	—	297
12	Vorinostat	—	299
13	Camptothecin	—	300
14	egcg	—	300
15	Celecoxib	—	295
16	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
17	kenpaullone	—	8
18	Kaempferols	—	300
19	alsterpaullone	—	12
20	Ursolic Acid	—	300
21	chrysin	—	300
22	scriptaid	—	53
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	Hexachlorophene	—	300
25	Valproic Acid	—	296
26	Butyric Acid	—	300
27	ly294002	—	11
28	Methylene Blue	—	200
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Sirolimus	—	300
31	tyrphostin ag 1478	—	4
32	cycloheximide	—	300
33	vinblastine sulfate	—	81
34	Disulfiram	—	297
35	Afatinib	—	297
36	Genistein	—	300
37	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
38	Colchicine	—	300
39	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
40	Masoprocol	—	300
41	Ciclopirox	—	88
42	Nisoldipine	—	297
43	Cladribine	—	297
44	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
45	Nocodazole Nocodazole is	—	215
46	Vemurafenib	—	298
47	Resveratrol	—	298
48	Dactinomycin	—	297
49	Rotenone	—	300
50	Niclosamide	—	299

About the Diseases of signal transduction by growth factor receptors and second messengers Pathway

The Diseases of signal transduction by growth factor receptors and second messengers pathway is catalogued in Reactome (ID: R-HSA-5663202) and involves 170 genes. In the BiohacksAI corpus, 503 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, ADRM1, AGO2, AKT3.