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BiohacksAI

Evidence-Based Biohacking

Patent Pending

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

REACTOME PATHWAY
Reactome: R-HSA-569356515 genes295 compounds

The Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks pathway (Reactome ID: R-HSA-5693565) involves 15 genes and is affected by 295 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1ATMBAP1BARD1BRCA1CHEK2EYA2KDM4AKDM4BMAPK8NSD2PPP5CSUMO1TP53UBE2N

Compounds Affecting Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

#CompoundTargets HitStudies
1Chlorhexidine—299
2Nocodazole Nocodazole is—215
3Astemizole Antihistamine drug now withdrawn from—280
4Hexachlorophene—300
5Axitinib—298
6Methotrexate—289
7Colchicine—300
8cycloheximide—300
9Melphalan—300
10sp600125—117
11Trifluridine—295
12vinblastine sulfate—81
13Azacitidine—298
14Azacitidine—300
15Ciclopirox—88
16Cytarabine—297
17Demecolcine—246
18Niclosamide—299
19triolimus [Supplementary Concept]—33
20Dasatinib—299
21Methylene Blue—200
22Podophyllotoxin—14
23Apigenin 5,7,4'-trihydroxy-flavone,—300
24Quercetin—300
25Sertraline—1,000
26alsterpaullone—12
27Fluspirilene—74
28kenpaullone—8
29lidoflazine—278
30Perphenazine—297
31Resveratrol—298
32rafoxanide—172
33Calcimycin—216
34Azathioprine—300
35Bortezomib—300
36Crizotinib—298
37Disulfiram—297
38Maprotiline—299
39alpelisib—227
40Clofarabine—298
41Decitabine—298
42Deferasirox—298
43Digitoxin—300
44Digoxin—299
45Emetine—298
46Ethidium—300
47monorden—8
48Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of—300
49pictilisib—25
50Sorafenib—300

About the Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Pathway

The Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks pathway is catalogued in Reactome (ID: R-HSA-5693565) and involves 15 genes. In the BiohacksAI corpus, 295 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ATM, BAP1, BARD1, BRCA1.