What genes are in the Processing of DNA double-strand break ends pathway?

The Processing of DNA double-strand break ends pathway involves 13 genes. Key genes include: ATM, BARD1, BLM, BRCA1, CCNA1, CDK2, CHEK1, DNA2, NSD2, RBBP8.

Processing of DNA double-strand break ends

Q: What compounds affect the Processing of DNA double-strand break ends pathway?

223 compounds in the BiohacksAI corpus have documented interactions with genes in the Processing of DNA double-strand break ends pathway (Reactome ID: R-HSA-5693607). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-569360713 genes223 compounds

The Processing of DNA double-strand break ends pathway (Reactome ID: R-HSA-5693607) involves 13 genes and is affected by 223 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BARD1 BLM BRCA1 CCNA1 CDK2 CHEK1 DNA2 NSD2 RBBP8 SIRT6 UBE2N WRN

Compounds Affecting Processing of DNA double-strand break ends

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	sp600125	—	117
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Astemizole Antihistamine drug now withdrawn from	—	280
5	kenpaullone	—	8
6	Methylene Blue	—	200
7	Methotrexate	—	289
8	Colchicine	—	300
9	cycloheximide	—	300
10	Melphalan	—	300
11	Nocodazole Nocodazole is	—	215
12	Podophyllotoxin	—	14
13	Trifluridine	—	295
14	vinblastine sulfate	—	81
15	Quercetin	—	300
16	alsterpaullone	—	12
17	Azacitidine	—	298
18	Azacitidine	—	300
19	Ciclopirox	—	88
20	Cytarabine	—	297
21	Demecolcine	—	246
22	Fluspirilene	—	74
23	Hexachlorophene	—	300
24	lidoflazine	—	278
25	Niclosamide	—	299
26	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
27	Ethidium	—	300
28	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
29	Daunorubicin	—	298
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Sertraline	—	1,000
32	Fluvastatin	—	297
33	Idarubicin	—	299
34	Perphenazine	—	297
35	Vitamin K 3	—	300
36	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
37	Resveratrol	—	298
38	Calcimycin	—	216
39	colchine	—	2
40	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
41	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
42	dihydrorotenone	—	13
43	gedunin	—	54
44	paxilline	—	42
45	rafoxanide	—	172
46	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
47	Tubercidin	—	300
48	Aurintricarboxylic Acid	—	184
49	Levodopa	—	297
50	streptonigrin	—	299

About the Processing of DNA double-strand break ends Pathway

The Processing of DNA double-strand break ends pathway is catalogued in Reactome (ID: R-HSA-5693607) and involves 13 genes. In the BiohacksAI corpus, 223 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BLM, BRCA1, CCNA1.