What genes are in the TP53 Regulates Transcription of DNA Repair Genes pathway?

The TP53 Regulates Transcription of DNA Repair Genes pathway involves 11 genes. Key genes include: ATM, BRCA1, CCNT2, CDK13, CDK7, CDK9, CHEK1, ERCC3, FOS, JUN.

TP53 Regulates Transcription of DNA Repair Genes

Q: What compounds affect the TP53 Regulates Transcription of DNA Repair Genes pathway?

219 compounds in the BiohacksAI corpus have documented interactions with genes in the TP53 Regulates Transcription of DNA Repair Genes pathway (Reactome ID: R-HSA-6796648). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-679664811 genes219 compounds

The TP53 Regulates Transcription of DNA Repair Genes pathway (Reactome ID: R-HSA-6796648) involves 11 genes and is affected by 219 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BRCA1 CCNT2 CDK13 CDK7 CDK9 CHEK1 ERCC3 FOS JUN TP53

Compounds Affecting TP53 Regulates Transcription of DNA Repair Genes

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	vinblastine sulfate	—	81
3	Nocodazole Nocodazole is	—	215
4	Colchicine	—	300
5	Hexachlorophene	—	300
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Rotenone	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
11	Cytarabine	—	297
12	Melphalan	—	300
13	Niclosamide	—	299
14	Methotrexate	—	289
15	Disulfiram	—	297
16	Vitamin K 3	—	300
17	Trifluridine	—	295
18	ninhydrin	—	300
19	Resveratrol	—	298
20	Ciclopirox	—	88
21	cycloheximide	—	300
22	Clotrimazole	—	296
23	Methylnitronitrosoguanidine	—	52
24	Thioridazine	—	35
25	Clofibrate	—	299
26	Fenofibrate	—	297
27	Nisoldipine	—	297
28	Oxyphenbutazone	—	300
29	rafoxanide	—	172
30	sp600125	—	117
31	triflupromazine hydrochloride	—	12
32	Vincristine	—	299
33	Sertraline	—	1,000
34	Amoxapine	—	259
35	Astemizole Antihistamine drug now withdrawn from	—	280
36	Chlorhexidine	—	299
37	Chlormadinone Acetate	—	300
38	Cinnarizine	—	299
39	Demecolcine	—	246
40	ethopropazine hydrochloride	—	2
41	Ethynodiol Diacetate	—	300
42	Maprotiline	—	299
43	Robenidine	—	162
44	Salmeterol Xinafoate	—	227
45	Tripterygium	—	300
46	Podophyllotoxin	—	14
47	Masoprocol	—	300
48	hydroxyfasudil [Supplementary Concept]	—	11
49	kenpaullone	—	8
50	Ethidium	—	300

About the TP53 Regulates Transcription of DNA Repair Genes Pathway

The TP53 Regulates Transcription of DNA Repair Genes pathway is catalogued in Reactome (ID: R-HSA-6796648) and involves 11 genes. In the BiohacksAI corpus, 219 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BRCA1, CCNT2, CDK13, CDK7.