What compounds affect the M Phase pathway?

116 compounds in the BiohacksAI corpus have documented interactions with genes in the M Phase pathway (Reactome ID: R-HSA-68886). These compounds target 84 genes within this pathway.

What genes are in the M Phase pathway?

The M Phase pathway involves 84 genes. Key genes include: ADRM1, AURKB, BIRC5, CCNB1, CCNB2, CDK1, CSNK1D, CSNK1E, CSNK2A1, CSNK2A2.

M Phase

REACTOME PATHWAY

Reactome: R-HSA-6888684 genes116 compounds

The M Phase pathway (Reactome ID: R-HSA-68886) involves 84 genes and is affected by 116 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AURKB BIRC5 CCNB1 CCNB2 CDK1 CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B EML4 HDAC8 HSP90AA1 KMT5A KPNB1 LMNA MAPK1 MAPK3 NEK2 NEK6 NEK7 NEK9 PLK1 PLK4 PPP1CC PPP2CA PPP2R5A PRKACA PSMA1+54 more

Compounds Affecting M Phase

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Reserpine	—	297
5	Vorinostat	—	299
6	Vincristine	—	299
7	Noscapine	—	300
8	Podophyllotoxin	—	14
9	Demecolcine	—	246
10	Maytansine	—	300
11	vinblastine sulfate	—	81
12	Quercetin	—	300
13	sp600125	—	117
14	alsterpaullone	—	12
15	kenpaullone	—	8
16	fisetin	—	78
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	chrysin	—	300
21	Sorafenib	—	300
22	Crizotinib	—	298
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
24	pictilisib	—	25
25	Kaempferols	—	300
26	Dasatinib	—	299
27	ly294002	—	11
28	Clotrimazole	—	296
29	Disulfiram	—	297
30	Hexachlorophene	—	300
31	plumbagin [Supplementary Concept]	—	300
32	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
33	Axitinib	—	298
34	indirubin	—	300
35	Vanillic Acid	—	300
36	Okadaic Acid	—	300
37	Masoprocol	—	300
38	2-Chloroadenosine 2-Chloroadenosine.	—	300
39	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
40	Calcimycin	—	216
41	Idarubicin	—	299
42	Wortmannin	—	300
43	pd98059	—	7
44	Lithocholic Acid	—	300
45	trametinib	—	296
46	withaferin	—	300
47	hydroxyfasudil [Supplementary Concept]	—	11
48	Oxytetracycline	—	300
49	egcg	—	300
50	trichostatic acid [Supplementary Concept] related to trichostatin	—	300

About the M Phase Pathway

The M Phase pathway is catalogued in Reactome (ID: R-HSA-68886) and involves 84 genes. In the BiohacksAI corpus, 116 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AURKB, BIRC5, CCNB1, CCNB2.