What compounds affect the G2/M DNA damage checkpoint pathway?

301 compounds in the BiohacksAI corpus have documented interactions with genes in the G2/M DNA damage checkpoint pathway (Reactome ID: R-HSA-69473). These compounds target 18 genes within this pathway.

What genes are in the G2/M DNA damage checkpoint pathway?

The G2/M DNA damage checkpoint pathway involves 18 genes. Key genes include: ATM, BARD1, BLM, BRCA1, CCNA1, CCNB1, CDK1, CHEK1, CHEK2, DNA2.

G2/M DNA damage checkpoint

REACTOME PATHWAY

Reactome: R-HSA-6947318 genes301 compounds

The G2/M DNA damage checkpoint pathway (Reactome ID: R-HSA-69473) involves 18 genes and is affected by 301 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BARD1 BLM BRCA1 CCNA1 CCNB1 CDK1 CHEK1 CHEK2 DNA2 NSD2 RBBP8 TP53 UBE2N WEE1 WRN YWHAB YWHAG

Compounds Affecting G2/M DNA damage checkpoint

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	kenpaullone	—	8
3	Chlorhexidine	—	299
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Quercetin	—	300
7	alsterpaullone	—	12
8	Astemizole Antihistamine drug now withdrawn from	—	280
9	Methylene Blue	—	200
10	Methotrexate	—	289
11	Colchicine	—	300
12	cycloheximide	—	300
13	Melphalan	—	300
14	Nocodazole Nocodazole is	—	215
15	Trifluridine	—	295
16	vinblastine sulfate	—	81
17	chrysin	—	300
18	Sertraline	—	1,000
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Ciclopirox	—	88
22	Cytarabine	—	297
23	Demecolcine	—	246
24	Hexachlorophene	—	300
25	Idarubicin	—	299
26	indirubin	—	300
27	Niclosamide	—	299
28	Ethidium	—	300
29	Podophyllotoxin	—	14
30	Daunorubicin	—	298
31	Clotrimazole	—	296
32	Fluspirilene	—	74
33	lidoflazine	—	278
34	Perphenazine	—	297
35	Rotenone	—	300
36	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
37	Vitamin K 3	—	300
38	Resveratrol	—	298
39	rafoxanide	—	172
40	Dasatinib	—	299
41	Axitinib	—	298
42	Azathioprine	—	300
43	Bortezomib	—	300
44	Disulfiram	—	297
45	Maprotiline	—	299
46	Clofarabine	—	298
47	Decitabine	—	298
48	Digitoxin	—	300
49	Digoxin	—	299
50	Emetine	—	298

About the G2/M DNA damage checkpoint Pathway

The G2/M DNA damage checkpoint pathway is catalogued in Reactome (ID: R-HSA-69473) and involves 18 genes. In the BiohacksAI corpus, 301 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BLM, BRCA1, CCNA1.