Cargo recognition for clathrin-mediated endocytosis

Q: What compounds affect the Cargo recognition for clathrin-mediated endocytosis pathway?

233 compounds in the BiohacksAI corpus have documented interactions with genes in the Cargo recognition for clathrin-mediated endocytosis pathway (Reactome ID: R-HSA-8856825). These compounds target 14 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-885682514 genes233 compounds

The Cargo recognition for clathrin-mediated endocytosis pathway (Reactome ID: R-HSA-8856825) involves 14 genes and is affected by 233 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AAK1 ADRB2 AGTR1 ARRB1 AVPR2 CFTR CHRM2 COPS5 EGFR GRB2 GRK2 NEDD8 TACR1 TOR1A

Compounds Affecting Cargo recognition for clathrin-mediated endocytosis

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Disulfiram	—	297
3	Carvedilol	—	296
4	Astemizole Antihistamine drug now withdrawn from	—	280
5	Amoxapine	—	259
6	candesartan cilexetil [Supplementary Concept]	—	300
7	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
8	Chlorhexidine	—	299
9	Nadolol	—	297
10	Hexachlorophene	—	300
11	Terbutaline	—	299
12	Hydroxyzine	—	298
13	Loratadine	—	296
14	Nicergoline	—	300
15	Nisoldipine	—	297
16	Anisomycin	—	247
17	Clotrimazole	—	296
18	Dinitrochlorobenzene	—	300
19	Maprotiline	—	299
20	Promazine	—	40
21	Loxapine	—	225
22	Nortriptyline	—	295
23	Oxyphenbutazone	—	300
24	Perphenazine	—	297
25	rafoxanide	—	172
26	Tolterodine Tartrate	—	73
27	Methylene Blue	—	200
28	Hyoscyamine	—	296
29	Flurandrenolone	—	65
30	Niclosamide	—	299
31	Tilorone	—	300
32	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
33	Quercetin	—	300
34	Axitinib	—	298
35	dofetilide	—	298
36	Flunarizine Flunarizine is	—	299
37	Propranolol	—	300
38	Levalbuterol	—	1,000
39	Levalbuterol	—	297
40	Alprenolol	—	300
41	Epinephrine	—	299
42	Norepinephrine Precursor of epinephrine that is secreted by	—	298
43	Levalbuterol	—	166
44	Atenolol	—	297
45	Pindolol	—	299
46	Timolol	—	298
47	Reserpine	—	297
48	Bupranolol	—	291
49	Clenbuterol	—	300
50	Fenoterol	—	300

About the Cargo recognition for clathrin-mediated endocytosis Pathway

The Cargo recognition for clathrin-mediated endocytosis pathway is catalogued in Reactome (ID: R-HSA-8856825) and involves 14 genes. In the BiohacksAI corpus, 233 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AAK1, ADRB2, AGTR1, ARRB1, AVPR2.