What genes are in the Regulation of MECP2 expression and activity pathway?

The Regulation of MECP2 expression and activity pathway involves 13 genes. Key genes include: AGO2, AURKB, CAMK2B, CAMK2D, CREB1, HDAC1, HDAC2, HDAC3, HIPK2, HTT.

Regulation of MECP2 expression and activity

Q: What compounds affect the Regulation of MECP2 expression and activity pathway?

100 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of MECP2 expression and activity pathway (Reactome ID: R-HSA-9022692). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-902269213 genes100 compounds

The Regulation of MECP2 expression and activity pathway (Reactome ID: R-HSA-9022692) involves 13 genes and is affected by 100 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 AURKB CAMK2B CAMK2D CREB1 HDAC1 HDAC2 HDAC3 HIPK2 HTT NCOR1 NCOR2 PRKACA

Compounds Affecting Regulation of MECP2 expression and activity

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Vorinostat	—	299
3	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
4	Bortezomib	—	300
5	sp600125	—	117
6	scriptaid	—	53
7	pictilisib	—	25
8	Quercetin	—	300
9	Sorafenib	—	300
10	Valproic Acid	—	296
11	Butyric Acid	—	300
12	Ursolic Acid	—	300
13	Celecoxib	—	295
14	Camptothecin	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	Dactinomycin	—	297
19	Ethidium	—	300
20	chrysin	—	300
21	Dasatinib	—	299
22	Oxyphenbutazone	—	300
23	kenpaullone	—	8
24	hydroxyfasudil [Supplementary Concept]	—	11
25	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
26	cycloheximide	—	300
27	Disulfiram	—	297
28	Levalbuterol	—	1,000
29	Adenosine Monophosphate Adenine nucleotide containing	—	300
30	Levalbuterol	—	297
31	Clofarabine	—	298
32	Danazol	—	298
33	Emetine	—	298
34	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
35	Sulbactam	—	299
36	trequinsin hydrochloride	—	1
37	Genistein	—	300
38	Testosterone	—	299
39	Ciclopirox	—	88
40	Cladribine	—	297
41	Clenbuterol	—	300
42	Corticosterone	—	300
43	Dinoprostone	—	296
44	Epinephrine	—	299
45	Ethinyl Estradiol	—	300
46	Imatinib Mesylate	—	300
47	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
48	Nisoldipine	—	297
49	Nocodazole Nocodazole is	—	215
50	Masoprocol	—	300

About the Regulation of MECP2 expression and activity Pathway

The Regulation of MECP2 expression and activity pathway is catalogued in Reactome (ID: R-HSA-9022692) and involves 13 genes. In the BiohacksAI corpus, 100 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, AURKB, CAMK2B, CAMK2D, CREB1.