What compounds affect the FOXO-mediated transcription pathway?

213 compounds in the BiohacksAI corpus have documented interactions with genes in the FOXO-mediated transcription pathway (Reactome ID: R-HSA-9614085). These compounds target 19 genes within this pathway.

What genes are in the FOXO-mediated transcription pathway?

The FOXO-mediated transcription pathway involves 19 genes. Key genes include: AKT3, BCL2L11, CREBBP, EP300, FOXO3, GCK, HDAC1, HDAC2, INS, KAT2B.

FOXO-mediated transcription

REACTOME PATHWAY

Reactome: R-HSA-961408519 genes213 compounds

The FOXO-mediated transcription pathway (Reactome ID: R-HSA-9614085) involves 19 genes and is affected by 213 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 BCL2L11 CREBBP EP300 FOXO3 GCK HDAC1 HDAC2 INS KAT2B MSTN NR3C1 SIRT1 SIRT3 SMAD2 SMAD3 SREBF1 YWHAB YWHAG

Compounds Affecting FOXO-mediated transcription

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Quercetin	—	300
3	Celecoxib	—	295
4	egcg	—	300
5	Bortezomib	—	300
6	Azacitidine	—	298
7	Azacitidine	—	300
8	cycloheximide	—	300
9	Ethinyl Estradiol	—	300
10	Danazol	—	298
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Dactinomycin	—	297
13	Vorinostat	—	299
14	Digitoxin	—	300
15	Equilin	—	216
16	Nisoldipine	—	297
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	chrysin	—	300
19	Kaempferols	—	300
20	Ciclopirox	—	88
21	Dasatinib	—	299
22	Emetine	—	298
23	Lynestrenol	—	299
24	o-Phthalaldehyde	—	300
25	Sulbactam	—	299
26	Colchicine	—	300
27	Flutamide	—	298
28	Nocodazole Nocodazole is	—	215
29	Masoprocol	—	300
30	Digoxin	—	299
31	Idarubicin	—	299
32	Anisomycin	—	247
33	Disulfiram	—	297
34	Dinitrochlorobenzene	—	300
35	Ethidium	—	300
36	Loratadine	—	296
37	Oxyphenbutazone	—	300
38	Podophyllotoxin	—	14
39	vinblastine sulfate	—	81
40	Vincristine	—	299
41	Fluoxetine	—	1,000
42	Methylene Blue	—	200
43	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
44	Astemizole Antihistamine drug now withdrawn from	—	280
45	Cladribine	—	297
46	Domperidone	—	299
47	Ezetimibe	—	296
48	Idazoxan	—	300
49	Perphenazine	—	297
50	pivampicillin	—	275

About the FOXO-mediated transcription Pathway

The FOXO-mediated transcription pathway is catalogued in Reactome (ID: R-HSA-9614085) and involves 19 genes. In the BiohacksAI corpus, 213 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, BCL2L11, CREBBP, EP300, FOXO3.