What compounds affect the Signaling by CSF3 (G-CSF) pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by CSF3 (G-CSF) pathway (Reactome ID: R-HSA-9674555). These compounds target 9 genes within this pathway.

What genes are in the Signaling by CSF3 (G-CSF) pathway?

The Signaling by CSF3 (G-CSF) pathway involves 9 genes. Key genes include: GRB2, HCK, JAK2, LYN, STAT1, STAT3, STAT5A, SYK, TYK2.

Signaling by CSF3 (G-CSF)

REACTOME PATHWAY

Reactome: R-HSA-96745559 genes210 compounds

The Signaling by CSF3 (G-CSF) pathway (Reactome ID: R-HSA-9674555) involves 9 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 HCK JAK2 LYN STAT1 STAT3 STAT5A SYK TYK2

Compounds Affecting Signaling by CSF3 (G-CSF)

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Sorafenib	—	300
3	Crizotinib	—	298
4	sp600125	—	117
5	tyrphostin ag 1478	—	4
6	Methylene Blue	—	200
7	Methotrexate	—	289
8	Niclosamide	—	299
9	Podophyllotoxin	—	14
10	Trifluridine	—	295
11	Axitinib	—	298
12	Azathioprine	—	300
13	Tripterygium	—	300
14	2-Methoxyestradiol	—	300
15	Afatinib	—	297
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Calcitriol	—	300
18	Camptothecin	—	300
19	Cladribine	—	297
20	Hexachlorophene	—	300
21	pictilisib	—	25
22	alsterpaullone	—	12
23	Cytarabine	—	297
24	kenpaullone	—	8
25	streptonigrin	—	299
26	Ouabain	—	300
27	Atorvastatin	—	1,000
28	Simvastatin	—	1,000
29	Chlorhexidine	—	299
30	Clofarabine	—	298
31	Colchicine	—	300
32	cycloheximide	—	300
33	deguelin [Supplementary Concept]	—	151
34	Digoxin	—	299
35	Disulfiram	—	297
36	Emetine	—	298
37	Ezetimibe	—	296
38	Lovastatin	—	300
39	Medroxyprogesterone Acetate	—	299
40	Melphalan	—	300
41	Mometasone Furoate	—	292
42	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
43	piceatannol	—	300
44	Thapsigargin	—	300
45	torin 1	—	10
46	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
47	fisetin	—	78
48	ag490	—	14
49	alpelisib	—	227
50	Bortezomib	—	300

About the Signaling by CSF3 (G-CSF) Pathway

The Signaling by CSF3 (G-CSF) pathway is catalogued in Reactome (ID: R-HSA-9674555) and involves 9 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, HCK, JAK2, LYN, STAT1.