What compounds affect the Cytoprotection by HMOX1 pathway?

301 compounds in the BiohacksAI corpus have documented interactions with genes in the Cytoprotection by HMOX1 pathway (Reactome ID: R-HSA-9707564). These compounds target 21 genes within this pathway.

What genes are in the Cytoprotection by HMOX1 pathway?

The Cytoprotection by HMOX1 pathway involves 21 genes. Key genes include: ABCC1, ALB, BLVRA, BLVRB, CARM1, COX1, COX2, CREBBP, HBA1, HBA2.

Cytoprotection by HMOX1

REACTOME PATHWAY

Reactome: R-HSA-970756421 genes301 compounds

The Cytoprotection by HMOX1 pathway (Reactome ID: R-HSA-9707564) involves 21 genes and is affected by 301 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ALB BLVRA BLVRB CARM1 COX1 COX2 CREBBP HBA1 HBA2 HBB HDAC3 NCOA1 NCOR1 NCOR2 NFE2L2 NLRP3 PPARA PTK6 RXRA STAT3

Compounds Affecting Cytoprotection by HMOX1

#	Compound	Targets Hit	Studies
1	Niclosamide	—	299
2	Celecoxib	—	295
3	Vorinostat	—	299
4	Azacitidine	—	298
5	Azacitidine	—	300
6	Quercetin	—	300
7	Bortezomib	—	300
8	Daunorubicin	—	298
9	Dihydrotestosterone	—	300
10	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
11	diallyl trisulfide	—	246
12	Colchicine	—	300
13	Vitamin	—	295
14	Genistein	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	alpha-Linolenic Acid	—	300
17	Rotenone	—	300
18	Methylene Blue	—	200
19	Nitrofurazone	—	300
20	Azathioprine	—	300
21	Digoxin	—	299
22	Flutamide	—	298
23	Hexachlorophene	—	300
24	Linoleic Acid	—	300
25	Vitamin K 3	—	300
26	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
27	Ethidium	—	300
28	Nocodazole Nocodazole is	—	215
29	Methotrexate	—	289
30	Lithocholic Acid	—	300
31	Retinaldehyde	—	300
32	Troglitazone	—	299
33	Kaempferols	—	300
34	Dactinomycin	—	297
35	Febuxostat	—	297
36	Fenofibrate	—	297
37	Niflumic Acid	—	300
38	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
39	dimethyl formamide	—	260
40	Dimethylformamide	—	300
41	Disulfiram	—	297
42	Sulindac	—	297
43	Thyroxine	—	994
44	Progesterone	—	299
45	Testosterone	—	299
46	Chlorhexidine	—	299
47	Cilostazol	—	297
48	Papaverine	—	299
49	Phenol	—	297
50	Thyroxine	—	300

About the Cytoprotection by HMOX1 Pathway

The Cytoprotection by HMOX1 pathway is catalogued in Reactome (ID: R-HSA-9707564) and involves 21 genes. In the BiohacksAI corpus, 301 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ALB, BLVRA, BLVRB, CARM1.