What compounds affect the Cellular response to chemical stress pathway?

420 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular response to chemical stress pathway (Reactome ID: R-HSA-9711123). These compounds target 87 genes within this pathway.

What genes are in the Cellular response to chemical stress pathway?

The Cellular response to chemical stress pathway involves 87 genes. Key genes include: ABCC1, ABCC3, ABCG2, ADRM1, AKT3, ALB, BCL2L1, BLVRA, BLVRB, BRCA1.

Cellular response to chemical stress

REACTOME PATHWAY

Reactome: R-HSA-971112387 genes420 compounds

The Cellular response to chemical stress pathway (Reactome ID: R-HSA-9711123) involves 87 genes and is affected by 420 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC3 ABCG2 ADRM1 AKT3 ALB BCL2L1 BLVRA BLVRB BRCA1 CARM1 CCL2 COX1 COX2 CREBBP CSNK2A1 CSNK2A2 CSNK2B CUL1 CYBB EIF2AK3 EP300 G6PD GPX1 GSK3B GSR GSTP1 HBA1 HBA2 HBB+57 more

Compounds Affecting Cellular response to chemical stress

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Reserpine	—	297
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	chrysin	—	300
8	Niclosamide	—	299
9	egcg	—	300
10	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
11	Hexachlorophene	—	300
12	ly294002	—	11
13	Azacitidine	—	298
14	Azacitidine	—	300
15	Methylene Blue	—	200
16	vinblastine sulfate	—	81
17	Methotrexate	—	289
18	Trifluridine	—	295
19	Ursolic Acid	—	300
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
21	Resveratrol	—	298
22	Genistein	—	300
23	Podophyllotoxin	—	14
24	Celecoxib	—	295
25	Daunorubicin	—	298
26	Oleanolic Acid	—	300
27	Disulfiram	—	297
28	Vorinostat	—	299
29	Chlorhexidine	—	299
30	cycloheximide	—	300
31	Rutin	—	300
32	fisetin	—	78
33	Colchicine	—	300
34	Rotenone	—	300
35	Azathioprine	—	300
36	Digoxin	—	299
37	Vitamin K 3	—	300
38	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
39	Nocodazole Nocodazole is	—	215
40	ninhydrin	—	300
41	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
42	Dihydrotestosterone	—	300
43	Febuxostat	—	297
44	Fenofibrate	—	297
45	sp600125	—	117
46	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
47	candesartan cilexetil [Supplementary Concept]	—	300
48	Lovastatin	—	300
49	Triamcinolone	—	300
50	Anisomycin	—	247

About the Cellular response to chemical stress Pathway

The Cellular response to chemical stress pathway is catalogued in Reactome (ID: R-HSA-9711123) and involves 87 genes. In the BiohacksAI corpus, 420 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC3, ABCG2, ADRM1, AKT3.