What compounds affect the Nuclear events mediated by NFE2L2 pathway?

311 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear events mediated by NFE2L2 pathway (Reactome ID: R-HSA-9759194). These compounds target 53 genes within this pathway.

What genes are in the Nuclear events mediated by NFE2L2 pathway?

The Nuclear events mediated by NFE2L2 pathway involves 53 genes. Key genes include: ABCC1, ABCC3, ABCG2, ADRM1, BCL2L1, CCL2, CREBBP, CUL1, EP300, G6PD.

Nuclear events mediated by NFE2L2

REACTOME PATHWAY

Reactome: R-HSA-975919453 genes311 compounds

The Nuclear events mediated by NFE2L2 pathway (Reactome ID: R-HSA-9759194) involves 53 genes and is affected by 311 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC3 ABCG2 ADRM1 BCL2L1 CCL2 CREBBP CUL1 EP300 G6PD GSK3B GSR IDH1 MYC NFE2L2 NFKB1 NQO1 PGD PRDX1 PRKAA2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3+23 more

Compounds Affecting Nuclear events mediated by NFE2L2

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	egcg	—	300
8	vinblastine sulfate	—	81
9	chrysin	—	300
10	Oleanolic Acid	—	300
11	Rutin	—	300
12	Resveratrol	—	298
13	Genistein	—	300
14	Methylene Blue	—	200
15	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
16	Niclosamide	—	299
17	Hexachlorophene	—	300
18	Podophyllotoxin	—	14
19	Methotrexate	—	289
20	ninhydrin	—	300
21	Daunorubicin	—	298
22	Disulfiram	—	297
23	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
24	candesartan cilexetil [Supplementary Concept]	—	300
25	Lovastatin	—	300
26	ly294002	—	11
27	Triamcinolone	—	300
28	Trifluridine	—	295
29	Delavirdine	—	296
30	Ursolic Acid	—	300
31	Colchicine	—	300
32	Azacitidine	—	298
33	Azacitidine	—	300
34	Rotenone	—	300
35	Azathioprine	—	300
36	alyssin [Supplementary Concept]	—	300
37	Digitoxin	—	300
38	Digoxin	—	299
39	Vitamin K 3	—	300
40	Nocodazole Nocodazole is	—	215
41	Dinitrochlorobenzene	—	300
42	Nisoldipine	—	297
43	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
44	Febuxostat	—	297
45	Fenofibrate	—	297
46	sp600125	—	117
47	Simvastatin	—	1,000
48	Mometasone Furoate	—	292
49	Masoprocol	—	300
50	Hydrocortisone	—	299

About the Nuclear events mediated by NFE2L2 Pathway

The Nuclear events mediated by NFE2L2 pathway is catalogued in Reactome (ID: R-HSA-9759194) and involves 53 genes. In the BiohacksAI corpus, 311 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC3, ABCG2, ADRM1, BCL2L1.