Transcriptional regulation of brown and beige adipocyte differentiation

Q: What compounds affect the Transcriptional regulation of brown and beige adipocyte differentiation pathway?

143 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation of brown and beige adipocyte differentiation pathway (Reactome ID: R-HSA-9843743). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98437436 genes143 compounds

The Transcriptional regulation of brown and beige adipocyte differentiation pathway (Reactome ID: R-HSA-9843743) involves 6 genes and is affected by 143 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HDAC1 HDAC2 NCOA1 PPARA PPARG RXRA

Compounds Affecting Transcriptional regulation of brown and beige adipocyte differentiation

#	Compound	Targets Hit	Studies
1	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
2	Arachidonic Acid	—	245
3	Daunorubicin	—	298
4	Ursolic Acid	—	300
5	Pioglitazone	—	297
6	Troglitazone	—	299
7	Methylene Blue	—	200
8	Thyroxine	—	994
9	Thyroxine	—	300
10	Genistein	—	300
11	Rotenone	—	300
12	urolithin b	—	49
13	alpha-Linolenic Acid	—	300
14	Bezafibrate	—	300
15	Linoleic Acid	—	300
16	Mepentol [Supplementary Concept]	—	184
17	Ethidium	—	300
18	Fenofibrate	—	297
19	Niflumic Acid	—	300
20	Oxaprozin	—	181
21	Prostaglandin D2	—	300
22	Dehydroepiandrosterone Sulfate	—	300
23	Oleic Acid	—	112
24	Quercetin	—	300
25	Vitamin	—	295
26	Methotrexate	—	289
27	cycloheximide	—	300
28	Dactinomycin	—	297
29	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
30	Ezetimibe	—	296
31	Famotidine	—	296
32	gamma-Linolenic Acid	—	300
33	Retinaldehyde	—	300
34	Aldosterone	—	300
35	Gemfibrozil	—	297
36	Vorinostat	—	299
37	scriptaid	—	53
38	Valproic Acid	—	296
39	pictilisib	—	25
40	Butyric Acid	—	300
41	Celecoxib	—	295
42	Bortezomib	—	300
43	Camptothecin	—	300
44	Indomethacin	—	297
45	Warfarin	—	1,000
46	Glyburide	—	298
47	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
48	sulindac sulfide	—	79
49	Triiodothyronine	—	300
50	Apigenin 5,7,4'-trihydroxy-flavone,	—	300

About the Transcriptional regulation of brown and beige adipocyte differentiation Pathway

The Transcriptional regulation of brown and beige adipocyte differentiation pathway is catalogued in Reactome (ID: R-HSA-9843743) and involves 6 genes. In the BiohacksAI corpus, 143 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HDAC1, HDAC2, NCOA1, PPARA, PPARG.