Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

Q: What compounds affect the Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway?

137 compounds in the BiohacksAI corpus have documented interactions with genes in the Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway (Reactome ID: R-HSA-9860927). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-986092715 genes137 compounds

The Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway (Reactome ID: R-HSA-9860927) involves 15 genes and is affected by 137 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ANXA2 CHUK IKBKB IKBKE ITGAV ITGB3 NFKB1 NFKBIA PDE4D PPP2CA PTPN1 RELA STAT1 YAP1

Compounds Affecting Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	chicoric acid	—	117
3	Resveratrol	—	298
4	Podophyllotoxin	—	14
5	Quercetin	—	300
6	Genistein	—	300
7	celastrol	—	300
8	Nocodazole Nocodazole is	—	215
9	Bortezomib	—	300
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	egcg	—	300
12	Kaempferols	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Rutin	—	300
15	Withania	—	500
16	Hexachlorophene	—	300
17	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
18	streptonigrin	—	299
19	tamarixetin	—	26
20	Trifluridine	—	295
21	tyrphostin ag 1478	—	4
22	withaferin	—	300
23	Adenosine Triphosphate	—	300
24	Ursolic Acid	—	300
25	Oleanolic Acid	—	300
26	alsterpaullone	—	12
27	Okadaic Acid	—	300
28	Methylene Blue	—	200
29	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
30	Colchicine	—	300
31	Daunorubicin	—	298
32	Rotenone	—	300
33	Pueraria	—	300
34	Azacitidine	—	298
35	Azacitidine	—	300
36	Camptothecin	—	300
37	cycloheximide	—	300
38	Dactinomycin	—	297
39	deguelin [Supplementary Concept]	—	151
40	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
41	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
42	Ouabain	—	300
43	Thapsigargin	—	300
44	Berberine	—	300
45	2-Methoxyestradiol	—	300
46	Anisomycin	—	247
47	Antimycin	—	300
48	Azauridine	—	300
49	Benzalkonium Compounds	—	299
50	Cetylpyridinium Cationic bactericidal surfactant used as	—	300

About the Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Pathway

The Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells pathway is catalogued in Reactome (ID: R-HSA-9860927) and involves 15 genes. In the BiohacksAI corpus, 137 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ANXA2, CHUK, IKBKB, IKBKE.