What compounds affect the Circadian clock pathway?

178 compounds in the BiohacksAI corpus have documented interactions with genes in the Circadian clock pathway (Reactome ID: R-HSA-9909396). These compounds target 59 genes within this pathway.

What genes are in the Circadian clock pathway?

The Circadian clock pathway involves 59 genes. Key genes include: ADRM1, CARM1, CDK5, CREB1, CREBBP, CSNK1D, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B.

Circadian clock

REACTOME PATHWAY

Reactome: R-HSA-990939659 genes178 compounds

The Circadian clock pathway (Reactome ID: R-HSA-9909396) involves 59 genes and is affected by 178 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CARM1 CDK5 CREB1 CREBBP CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B CUL1 EP300 HDAC3 KMT2A NCOA1 NCOR1 NR1D1 PPARA PPP1CA PPP1CC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3+29 more

Compounds Affecting Circadian clock

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	chrysin	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	egcg	—	300
9	Aldosterone	—	300
10	fisetin	—	78
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	sp600125	—	117
13	pictilisib	—	25
14	Genistein	—	300
15	Gemfibrozil	—	297
16	Dasatinib	—	299
17	Kaempferols	—	300
18	Vanillic Acid	—	300
19	ly294002	—	11
20	alsterpaullone	—	12
21	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
22	Thyroxine	—	994
23	Progesterone	—	299
24	Dactinomycin	—	297
25	Thyroxine	—	300
26	Arachidonic Acid	—	245
27	Testosterone	—	299
28	Ethidium	—	300
29	cycloheximide	—	300
30	Disulfiram	—	297
31	Azacitidine	—	298
32	Azacitidine	—	300
33	Cladribine	—	297
34	Daunorubicin	—	298
35	Nocodazole Nocodazole is	—	215
36	Pioglitazone	—	297
37	Ursolic Acid	—	300
38	kenpaullone	—	8
39	Hexachlorophene	—	300
40	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
41	Aurintricarboxylic Acid	—	184
42	Vorinostat	—	299
43	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
44	s adenosylhomocysteine	—	300
45	Suramin	—	300
46	ninhydrin	—	300
47	Dehydroepiandrosterone Sulfate	—	300
48	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
49	Sulindac	—	297
50	Vitamin	—	295

About the Circadian clock Pathway

The Circadian clock pathway is catalogued in Reactome (ID: R-HSA-9909396) and involves 59 genes. In the BiohacksAI corpus, 178 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CARM1, CDK5, CREB1, CREBBP.