Epigenetic regulation by WDR5-containing histone modifying complexes

Q: What compounds affect the Epigenetic regulation by WDR5-containing histone modifying complexes pathway?

201 compounds in the BiohacksAI corpus have documented interactions with genes in the Epigenetic regulation by WDR5-containing histone modifying complexes pathway (Reactome ID: R-HSA-9917777). These compounds target 27 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-991777727 genes201 compounds

The Epigenetic regulation by WDR5-containing histone modifying complexes pathway (Reactome ID: R-HSA-9917777) involves 27 genes and is affected by 201 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ASH2L CCNC CDK5 CDK8 CREBBP DPY30 EP300 FABP4 HDAC3 KAT2A KAT2B KMT2A MEN1 MGLL NCOA1 NCOA3 NCOR1 NCOR2 NR5A2 PLIN1 PPARG PSIP1 RBBP5 RXRA SIRT1 WDR5

Compounds Affecting Epigenetic regulation by WDR5-containing histone modifying complexes

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	s adenosylhomocysteine	—	300
3	Ethidium	—	300
4	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
5	Arachidonic Acid	—	245
6	Methotrexate	—	289
7	Biotin	—	297
8	cycloheximide	—	300
9	Sorafenib	—	300
10	alsterpaullone	—	12
11	Genistein	—	300
12	urolithin b	—	49
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Oleic Acid	—	112
15	Quercetin	—	300
16	Nocodazole Nocodazole is	—	215
17	Anisomycin	—	247
18	Azacitidine	—	298
19	Azacitidine	—	300
20	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
21	Digoxin	—	299
22	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
23	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
24	Tubercidin	—	300
25	egcg	—	300
26	Vorinostat	—	299
27	Thyroxine	—	994
28	Thyroxine	—	300
29	Rotenone	—	300
30	alpha-Linolenic Acid	—	300
31	Linoleic Acid	—	300
32	Triiodothyronine	—	300
33	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
34	chrysin	—	300
35	Resveratrol	—	298
36	candesartan cilexetil [Supplementary Concept]	—	300
37	Disulfiram	—	297
38	Niflumic Acid	—	300
39	Oxaprozin	—	181
40	Dehydroepiandrosterone Sulfate	—	300
41	Vitamin	—	295
42	Dactinomycin	—	297
43	Dasatinib	—	299
44	Daunorubicin	—	298
45	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
46	Edaravone	—	298
47	Ezetimibe	—	296
48	Famotidine	—	296
49	gamma-Linolenic Acid	—	300
50	Hexachlorophene	—	300

About the Epigenetic regulation by WDR5-containing histone modifying complexes Pathway

The Epigenetic regulation by WDR5-containing histone modifying complexes pathway is catalogued in Reactome (ID: R-HSA-9917777) and involves 27 genes. In the BiohacksAI corpus, 201 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ASH2L, CCNC, CDK5, CDK8.