What compounds affect the Expression of BMAL (ARNTL), CLOCK, and NPAS2 pathway?

139 compounds in the BiohacksAI corpus have documented interactions with genes in the Expression of BMAL (ARNTL), CLOCK, and NPAS2 pathway (Reactome ID: R-HSA-9931509). These compounds target 13 genes within this pathway.

What genes are in the Expression of BMAL (ARNTL), CLOCK, and NPAS2 pathway?

The Expression of BMAL (ARNTL), CLOCK, and NPAS2 pathway involves 13 genes. Key genes include: CARM1, CREB1, CREBBP, EP300, HDAC3, NCOA1, NCOR1, NR1D1, PPARA, RORA.

Expression of BMAL (ARNTL), CLOCK, and NPAS2

REACTOME PATHWAY

Reactome: R-HSA-993150913 genes139 compounds

The Expression of BMAL (ARNTL), CLOCK, and NPAS2 pathway (Reactome ID: R-HSA-9931509) involves 13 genes and is affected by 139 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREB1 CREBBP EP300 HDAC3 NCOA1 NCOR1 NR1D1 PPARA RORA RORB RXRA SIRT1

Compounds Affecting Expression of BMAL (ARNTL), CLOCK, and NPAS2

#	Compound	Targets Hit	Studies
1	Aldosterone	—	300
2	Gemfibrozil	—	297
3	Progesterone	—	299
4	Dactinomycin	—	297
5	Arachidonic Acid	—	245
6	Genistein	—	300
7	Quercetin	—	300
8	Testosterone	—	299
9	Ethidium	—	300
10	cycloheximide	—	300
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Bortezomib	—	300
14	Cladribine	—	297
15	Daunorubicin	—	298
16	Nocodazole Nocodazole is	—	215
17	Ursolic Acid	—	300
18	Vorinostat	—	299
19	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
20	Dehydroepiandrosterone Sulfate	—	300
21	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
22	Sulindac	—	297
23	Thyroxine	—	994
24	Vitamin	—	295
25	Calcitriol	—	300
26	Domperidone	—	299
27	Ethylene Chlorohydrin Used as	—	73
28	Phenol	—	297
29	Retinaldehyde	—	300
30	Ribitol	—	297
31	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
32	Stavudine	—	298
33	Sulfanilamide	—	300
34	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
35	Thyroxine	—	300
36	Xylitol	—	300
37	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
38	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
39	Acetylcysteine	—	298
40	Adenosine	—	298
41	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
42	Chloral Hydrate	—	298
43	Chloralose	—	300
44	Cilostazol	—	297
45	Diflubenzuron	—	300
46	Dihydrotestosterone	—	300
47	dimethyl formamide	—	260
48	Dimethylformamide	—	300
49	Diuron	—	300
50	Ezetimibe	—	296

About the Expression of BMAL (ARNTL), CLOCK, and NPAS2 Pathway

The Expression of BMAL (ARNTL), CLOCK, and NPAS2 pathway is catalogued in Reactome (ID: R-HSA-9931509) and involves 13 genes. In the BiohacksAI corpus, 139 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREB1, CREBBP, EP300, HDAC3.