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BiohacksAI/Compounds/Guanfacine/Similar

Compounds Similar to Guanfacine

10 compounds with shared biological targets · BiohacksAI corpus v20260307-01

The compounds below share molecular targets and biological mechanisms with Guanfacine, including interactions with 5-HYDROXYTRYPTAMINE, ADRA2A, CYP3A4. Similarity is calculated using target-weighted Jaccard scoring across the BiohacksAI BindingDB corpus. Higher shared target counts indicate stronger mechanistic overlap.

View Guanfacine profile →DOPAMINE SEROTONIN pathwayCORTISOL STRESS pathway
Similar Compounds — Ranked by Target Overlap
1
Oxymetazoline
15
shared
298
studies
46%
overlap
2
Clonidineheterocyclic
13
shared
299
studies
39%
overlap
3
Phentolamine
15
shared
300
studies
38%
overlap
4
Dexmedetomidine
10
shared
299
studies
37%
overlap
5
Rilmenidine
9
shared
300
studies
37%
overlap
6
Dihydroergocornine
8
shared
65
studies
30%
overlap
7
Nylidrin
10
shared
90
studies
30%
overlap
8
Ergotamine
12
shared
299
studies
29%
overlap
9
Guanabenz
13
shared
298
studies
29%
overlap
10
Dihydroergotamine
15
shared
299
studies
28%
overlap
Shared Biological Targets
ADRA2AADRA2CADRA2BADRA1A5-HYDROXYTRYPTAMINEADRA1DADRA1BALPHA-2A

Click a target to see all compounds with interactions at that molecular target.

Similarity between compounds is computed using IDF-weighted Jaccard scoring across shared molecular targets in the BiohacksAI BindingDB corpus. Compounds with higher overlap scores share more targets, weighted by how specific those targets are across the entire corpus.

Explore related resources: Guanfacine full profile · Browse all compounds · Biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.