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BiohacksAI/Compounds/Protriptyline/Similar

Compounds Similar to Protriptyline

10 compounds with shared biological targets · BiohacksAI corpus v20260307-01

The compounds below share molecular targets and biological mechanisms with Protriptyline, including interactions with CYP2D6, CHRM1, CHAIN. Similarity is calculated using target-weighted Jaccard scoring across the BiohacksAI BindingDB corpus. Higher shared target counts indicate stronger mechanistic overlap.

View Protriptyline profile →DOPAMINE SEROTONIN pathwayCALCIUM SIGNALING pathway
Similar Compounds — Ranked by Target Overlap
1
Chlorpheniramine
13
shared
298
studies
43%
overlap
2
Nefopamheterocyclic
11
shared
299
studies
36%
overlap
3
prochlorperazine
14
shared
31%
overlap
4
Promethazine
21
shared
296
studies
31%
overlap
5
Hydroxyzine
15
shared
298
studies
31%
overlap
6
Lidoflazine
16
shared
278
studies
31%
overlap
7
Aprindine
9
shared
300
studies
30%
overlap
8
clomipramine
13
shared
30%
overlap
9
orphenadrine
11
shared
29%
overlap
10
promazine
13
shared
29%
overlap
Shared Biological Targets
HRH15-HYDROXYTRYPTAMINEADRA1AADRA2BCHRM1CHRM2CYP2D6ADRB2

Click a target to see all compounds with interactions at that molecular target.

Similarity between compounds is computed using IDF-weighted Jaccard scoring across shared molecular targets in the BiohacksAI BindingDB corpus. Compounds with higher overlap scores share more targets, weighted by how specific those targets are across the entire corpus.

Explore related resources: Protriptyline full profile · Browse all compounds · Biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.