What compounds affect the Apoptosis pathway?

190 compounds in the BiohacksAI corpus have documented interactions with genes in the Apoptosis pathway (Reactome ID: R-HSA-109581). These compounds target 54 genes within this pathway.

What genes are in the Apoptosis pathway?

The Apoptosis pathway involves 54 genes. Key genes include: ADRM1, AKT3, BAD, BCL2L1, BCL2L11, BMX, CASP9, DAPK1, DAPK2, DAPK3.

Apoptosis

REACTOME PATHWAY

Reactome: R-HSA-10958154 genes190 compounds

The Apoptosis pathway (Reactome ID: R-HSA-109581) involves 54 genes and is affected by 190 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 BAD BCL2L1 BCL2L11 BMX CASP9 DAPK1 DAPK2 DAPK3 FNTA GSDMD HMGB1 KPNB1 LMNA MAPK1 MAPK3 MAPK8 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5+24 more

Compounds Affecting Apoptosis

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	sp600125	—	117
4	Quercetin	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Disulfiram	—	297
7	plumbagin [Supplementary Concept]	—	300
8	pd98059	—	7
9	withaferin	—	300
10	pictilisib	—	25
11	Methylene Blue	—	200
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
14	Niclosamide	—	299
15	Methotrexate	—	289
16	Axitinib	—	298
17	Genistein	—	300
18	daph	—	2
19	Loratadine	—	296
20	Clotrimazole	—	296
21	vinblastine sulfate	—	81
22	chrysin	—	300
23	Benzalkonium Compounds	—	299
24	Harmaline	—	300
25	Idarubicin	—	299
26	Progesterone	—	299
27	2-Chloroadenosine 2-Chloroadenosine.	—	300
28	Chlorhexidine	—	299
29	Dasatinib	—	299
30	alsterpaullone	—	12
31	kenpaullone	—	8
32	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
33	Sorafenib	—	300
34	trametinib	—	296
35	egcg	—	300
36	Masoprocol	—	300
37	Anisomycin	—	247
38	hydroxyfasudil [Supplementary Concept]	—	11
39	Crizotinib	—	298
40	Ethidium	—	300
41	Ethinyl Estradiol	—	300
42	Hexachlorophene	—	300
43	Azacitidine	—	298
44	Azacitidine	—	300
45	Rotenone	—	300
46	Azathioprine	—	300
47	Cladribine	—	297
48	Cytarabine	—	297
49	Melphalan	—	300
50	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300

About the Apoptosis Pathway

The Apoptosis pathway is catalogued in Reactome (ID: R-HSA-109581) and involves 54 genes. In the BiohacksAI corpus, 190 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, BAD, BCL2L1, BCL2L11.