What compounds affect the Cell Cycle pathway?

383 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell Cycle pathway (Reactome ID: R-HSA-1640170). These compounds target 144 genes within this pathway.

What genes are in the Cell Cycle pathway?

The Cell Cycle pathway involves 144 genes. Key genes include: ABL1, ADRM1, AKT3, ATM, AURKA, AURKB, BARD1, BIRC5, BLM, BRCA1.

Cell Cycle

REACTOME PATHWAY

Reactome: R-HSA-1640170144 genes383 compounds

The Cell Cycle pathway (Reactome ID: R-HSA-1640170) involves 144 genes and is affected by 383 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AKT3 ATM AURKA AURKB BARD1 BIRC5 BLM BRCA1 CCNA1 CCNB1 CCNB2 CCNE2 CDC25A CDC25B CDC7 CDK1 CDK11A CDK11B CDK2 CDK4 CDK6 CDK7 CHEK1 CHEK2 CSNK1A1 CSNK1D CSNK1E CSNK2A1+114 more

Compounds Affecting Cell Cycle

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Podophyllotoxin	—	14
5	sp600125	—	117
6	vinblastine sulfate	—	81
7	Quercetin	—	300
8	Demecolcine	—	246
9	kenpaullone	—	8
10	Vorinostat	—	299
11	Vincristine	—	299
12	Sorafenib	—	300
13	alsterpaullone	—	12
14	Reserpine	—	297
15	Noscapine	—	300
16	Dasatinib	—	299
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	Maytansine	—	300
19	Crizotinib	—	298
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	fisetin	—	78
23	chrysin	—	300
24	Hexachlorophene	—	300
25	Astemizole Antihistamine drug now withdrawn from	—	280
26	indirubin	—	300
27	Methylene Blue	—	200
28	Methotrexate	—	289
29	Chlorhexidine	—	299
30	pictilisib	—	25
31	Trifluridine	—	295
32	Cytarabine	—	297
33	Idarubicin	—	299
34	Niclosamide	—	299
35	Axitinib	—	298
36	cycloheximide	—	300
37	Azacitidine	—	298
38	Azacitidine	—	300
39	Ciclopirox	—	88
40	ly294002	—	11
41	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
42	plumbagin [Supplementary Concept]	—	300
43	Calcimycin	—	216
44	gedunin	—	54
45	egcg	—	300
46	Disulfiram	—	297
47	Ethidium	—	300
48	Melphalan	—	300
49	withaferin	—	300
50	Daunorubicin	—	298

About the Cell Cycle Pathway

The Cell Cycle pathway is catalogued in Reactome (ID: R-HSA-1640170) and involves 144 genes. In the BiohacksAI corpus, 383 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AKT3, ATM, AURKA.