What compounds affect the Immune System pathway?

735 compounds in the BiohacksAI corpus have documented interactions with genes in the Immune System pathway (Reactome ID: R-HSA-168256). These compounds target 361 genes within this pathway.

What genes are in the Immune System pathway?

The Immune System pathway involves 361 genes. Key genes include: ABL1, ABL2, ADAM10, ADAM17, ADRM1, AGL, AGO2, AKT3, ALOX15, ALOX5.

Immune System

REACTOME PATHWAY

Reactome: R-HSA-168256361 genes735 compounds

The Immune System pathway (Reactome ID: R-HSA-168256) involves 361 genes and is affected by 735 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ABL2 ADAM10 ADAM17 ADRM1 AGL AGO2 AKT3 ALOX15 ALOX5 AMPD3 ANXA2 AOC1 APP ARSA ASH2L ATF6 ATP6V1B2 BCL2L1 BCL2L11 BIRC5 BLK BRD4 BTK C5 C9 CA1 CAMK2B CAMK2D CAPN1+331 more

Compounds Affecting Immune System

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Sorafenib	—	300
4	Crizotinib	—	298
5	sp600125	—	117
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Colchicine	—	300
9	Podophyllotoxin	—	14
10	Nocodazole Nocodazole is	—	215
11	Dasatinib	—	299
12	vinblastine sulfate	—	81
13	Hexachlorophene	—	300
14	Axitinib	—	298
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Kaempferols	—	300
17	Disulfiram	—	297
18	Vincristine	—	299
19	alsterpaullone	—	12
20	kenpaullone	—	8
21	cycloheximide	—	300
22	Niclosamide	—	299
23	Afatinib	—	297
24	Reserpine	—	297
25	Resveratrol	—	298
26	Masoprocol	—	300
27	tyrphostin ag 1478	—	4
28	pictilisib	—	25
29	Noscapine	—	300
30	egcg	—	300
31	Methylene Blue	—	200
32	Vorinostat	—	299
33	ly294002	—	11
34	Demecolcine	—	246
35	Anisomycin	—	247
36	Genistein	—	300
37	Rotenone	—	300
38	chrysin	—	300
39	fisetin	—	78
40	Ursolic Acid	—	300
41	Digoxin	—	299
42	Oleanolic Acid	—	300
43	Maytansine	—	300
44	Clotrimazole	—	296
45	Camptothecin	—	300
46	celastrol	—	300
47	Idarubicin	—	299
48	Sirolimus	—	300
49	Daunorubicin	—	298
50	withaferin	—	300

About the Immune System Pathway

The Immune System pathway is catalogued in Reactome (ID: R-HSA-168256) and involves 361 genes. In the BiohacksAI corpus, 735 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ABL2, ADAM10, ADAM17, ADRM1.