What genes are in the Fcgamma receptor (FCGR) dependent phagocytosis pathway?

The Fcgamma receptor (FCGR) dependent phagocytosis pathway involves 21 genes. Key genes include: ABL1, BTK, CDC42, CFL1, FGR, FYN, GRB2, HCK, HSP90AA1, HSP90AB1.

Fcgamma receptor (FCGR) dependent phagocytosis

Q: What compounds affect the Fcgamma receptor (FCGR) dependent phagocytosis pathway?

242 compounds in the BiohacksAI corpus have documented interactions with genes in the Fcgamma receptor (FCGR) dependent phagocytosis pathway (Reactome ID: R-HSA-2029480). These compounds target 21 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-202948021 genes242 compounds

The Fcgamma receptor (FCGR) dependent phagocytosis pathway (Reactome ID: R-HSA-2029480) involves 21 genes and is affected by 242 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 BTK CDC42 CFL1 FGR FYN GRB2 HCK HSP90AA1 HSP90AB1 LIMK1 LYN MAPK1 MAPK3 PIK3CB PIK3R1 PIK3R2 PLD2 SRC SYK YES1

Compounds Affecting Fcgamma receptor (FCGR) dependent phagocytosis

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	Crizotinib	—	298
5	kenpaullone	—	8
6	Quercetin	—	300
7	alsterpaullone	—	12
8	pictilisib	—	25
9	alpelisib	—	227
10	Axitinib	—	298
11	Afatinib	—	297
12	Clotrimazole	—	296
13	ly294002	—	11
14	monorden	—	8
15	triolimus [Supplementary Concept]	—	33
16	sp600125	—	117
17	piceatannol	—	300
18	ag490	—	14
19	withaferin	—	300
20	celastrol	—	300
21	Idarubicin	—	299
22	pd98059	—	7
23	Tetracycline	—	300
24	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	Wortmannin	—	300
27	Sirolimus	—	300
28	cycloheximide	—	300
29	deguelin [Supplementary Concept]	—	151
30	Disulfiram	—	297
31	Niclosamide	—	299
32	torin 1	—	10
33	fisetin	—	78
34	Nocodazole Nocodazole is	—	215
35	Sertraline	—	1,000
36	Calcitriol	—	300
37	casin	—	10
38	Cladribine	—	297
39	Hexachlorophene	—	300
40	Rotenone	—	300
41	trequinsin hydrochloride	—	1
42	Vemurafenib	—	298
43	Kaempferols	—	300
44	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
45	Ciclopirox	—	88
46	daph	—	2
47	Loratadine	—	296
48	Miconazole	—	298
49	gedunin	—	54
50	Novobiocin	—	300

About the Fcgamma receptor (FCGR) dependent phagocytosis Pathway

The Fcgamma receptor (FCGR) dependent phagocytosis pathway is catalogued in Reactome (ID: R-HSA-2029480) and involves 21 genes. In the BiohacksAI corpus, 242 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, BTK, CDC42, CFL1, FGR.