What compounds affect the Biological oxidations pathway?

707 compounds in the BiohacksAI corpus have documented interactions with genes in the Biological oxidations pathway (Reactome ID: R-HSA-211859). These compounds target 57 genes within this pathway.

What genes are in the Biological oxidations pathway?

The Biological oxidations pathway involves 57 genes. Key genes include: AADAC, AHCY, AHR, ALDH1A1, ALDH2, AOC1, ARNT, CBR3, CES1, CES2.

Biological oxidations

REACTOME PATHWAY

Reactome: R-HSA-21185957 genes707 compounds

The Biological oxidations pathway (Reactome ID: R-HSA-211859) involves 57 genes and is affected by 707 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AADAC AHCY AHR ALDH1A1 ALDH2 AOC1 ARNT CBR3 CES1 CES2 CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP24A1 CYP2A13 CYP2A6 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2J2 CYP3A4 CYP3A43 CYP3A5 CYP3A7+27 more

Compounds Affecting Biological oxidations

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Quercetin	—	300
3	Disulfiram	—	297
4	Clotrimazole	—	296
5	Vitamin K 3	—	300
6	Methylene Blue	—	200
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	Chlorhexidine	—	299
9	chrysin	—	300
10	Miconazole	—	298
11	Flutamide	—	298
12	Ethidium	—	300
13	Ritonavir	—	298
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Ethinyl Estradiol	—	300
17	Methoxsalen	—	300
18	Genistein	—	300
19	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
20	Pueraria	—	300
21	Kaempferols	—	300
22	Voriconazole	—	299
23	cbd	—	298
24	cannabidiol	—	296
25	Edaravone	—	298
26	Rotenone	—	300
27	Nisoldipine	—	297
28	Danazol	—	298
29	Troglitazone	—	299
30	Reserpine	—	297
31	Simvastatin	—	1,000
32	Niclosamide	—	299
33	Thyroxine	—	994
34	Thyroxine	—	300
35	Carbaryl	—	300
36	Sulindac	—	297
37	Melatonin	—	297
38	Anastrozole	—	298
39	Lynestrenol	—	299
40	Melphalan	—	300
41	Nitrofurazone	—	300
42	Phenelzine	—	297
43	Phenelzine	—	2
44	Piperonyl Butoxide	—	300
45	Podophyllotoxin	—	14
46	Fluvoxamine	—	297
47	amlexanox	—	96
48	Amoxapine	—	259
49	Axitinib	—	298
50	Dihydrotestosterone	—	300

About the Biological oxidations Pathway

The Biological oxidations pathway is catalogued in Reactome (ID: R-HSA-211859) and involves 57 genes. In the BiohacksAI corpus, 707 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AADAC, AHCY, AHR, ALDH1A1, ALDH2.