What compounds affect the Phase I - Functionalization of compounds pathway?

690 compounds in the BiohacksAI corpus have documented interactions with genes in the Phase I - Functionalization of compounds pathway (Reactome ID: R-HSA-211945). These compounds target 45 genes within this pathway.

What genes are in the Phase I - Functionalization of compounds pathway?

The Phase I - Functionalization of compounds pathway involves 45 genes. Key genes include: AADAC, AHR, ALDH1A1, ALDH2, AOC1, ARNT, CBR3, CES1, CES2, CYP11B1.

Phase I - Functionalization of compounds

REACTOME PATHWAY

Reactome: R-HSA-21194545 genes690 compounds

The Phase I - Functionalization of compounds pathway (Reactome ID: R-HSA-211945) involves 45 genes and is affected by 690 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AADAC AHR ALDH1A1 ALDH2 AOC1 ARNT CBR3 CES1 CES2 CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP24A1 CYP2A13 CYP2A6 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2J2 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P+15 more

Compounds Affecting Phase I - Functionalization of compounds

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	Clotrimazole	—	296
3	Quercetin	—	300
4	Disulfiram	—	297
5	Vitamin K 3	—	300
6	chrysin	—	300
7	Methylene Blue	—	200
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	Miconazole	—	298
10	Flutamide	—	298
11	Chlorhexidine	—	299
12	Ethidium	—	300
13	Methoxsalen	—	300
14	Genistein	—	300
15	Kaempferols	—	300
16	Voriconazole	—	299
17	cbd	—	298
18	cannabidiol	—	296
19	Ritonavir	—	298
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	Ethinyl Estradiol	—	300
22	Rotenone	—	300
23	Nisoldipine	—	297
24	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
25	Pueraria	—	300
26	Danazol	—	298
27	Troglitazone	—	299
28	Reserpine	—	297
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Simvastatin	—	1,000
31	Niclosamide	—	299
32	Carbaryl	—	300
33	Sulindac	—	297
34	Melatonin	—	297
35	Lynestrenol	—	299
36	Melphalan	—	300
37	Nitrofurazone	—	300
38	Phenelzine	—	297
39	Phenelzine	—	2
40	Piperonyl Butoxide	—	300
41	Podophyllotoxin	—	14
42	Fluvoxamine	—	297
43	amlexanox	—	96
44	Amoxapine	—	259
45	Axitinib	—	298
46	Dihydrotestosterone	—	300
47	Edaravone	—	298
48	Retinaldehyde	—	300
49	trequinsin hydrochloride	—	1
50	Kaempferols	—	300

About the Phase I - Functionalization of compounds Pathway

The Phase I - Functionalization of compounds pathway is catalogued in Reactome (ID: R-HSA-211945) and involves 45 genes. In the BiohacksAI corpus, 690 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AADAC, AHR, ALDH1A1, ALDH2, AOC1.