What compounds affect the Endogenous sterols pathway?

258 compounds in the BiohacksAI corpus have documented interactions with genes in the Endogenous sterols pathway (Reactome ID: R-HSA-211976). These compounds target 12 genes within this pathway.

What genes are in the Endogenous sterols pathway?

The Endogenous sterols pathway involves 12 genes. Key genes include: AHR, ARNT, CYP11B1, CYP11B2, CYP19A1, CYP1B1, CYP46A1, CYP51A1, CYP8B1, NCOA1.

Endogenous sterols

REACTOME PATHWAY

Reactome: R-HSA-21197612 genes258 compounds

The Endogenous sterols pathway (Reactome ID: R-HSA-211976) involves 12 genes and is affected by 258 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHR ARNT CYP11B1 CYP11B2 CYP19A1 CYP1B1 CYP46A1 CYP51A1 CYP8B1 NCOA1 NR1H4 RXRA

Compounds Affecting Endogenous sterols

#	Compound	Targets Hit	Studies
1	Clotrimazole	—	296
2	chrysin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Methylene Blue	—	200
5	Ethidium	—	300
6	Miconazole	—	298
7	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
8	Quercetin	—	300
9	Letrozole	—	298
10	Fadrozole	—	300
11	cycloheximide	—	300
12	Dactinomycin	—	297
13	Dihydrotestosterone	—	300
14	Rotenone	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Kaempferols	—	300
18	Niclosamide	—	299
19	Nitrofurazone	—	300
20	Retinaldehyde	—	300
21	trequinsin hydrochloride	—	1
22	Genistein	—	300
23	Thyroxine	—	994
24	Thyroxine	—	300
25	Resveratrol	—	298
26	Kaempferols	—	300
27	Testosterone	—	299
28	Fulvestrant	—	295
29	Reserpine	—	297
30	Spironolactone	—	298
31	Vitamin	—	295
32	Disulfiram	—	297
33	Chlorhexidine	—	299
34	Daunorubicin	—	298
35	Digoxin	—	299
36	Dinitrochlorobenzene	—	300
37	Emetine	—	298
38	Flutamide	—	298
39	Nisoldipine	—	297
40	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
41	Troglitazone	—	299
42	Atorvastatin	—	1,000
43	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
44	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
45	Simvastatin	—	1,000
46	Adapalene	—	296
47	Carbazilquinone	—	48
48	Dasatinib	—	299
49	Idazoxan	—	300
50	Levonorgestrel	—	292

About the Endogenous sterols Pathway

The Endogenous sterols pathway is catalogued in Reactome (ID: R-HSA-211976) and involves 12 genes. In the BiohacksAI corpus, 258 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHR, ARNT, CYP11B1, CYP11B2, CYP19A1.