What compounds affect the Generic Transcription Pathway pathway?

802 compounds in the BiohacksAI corpus have documented interactions with genes in the Generic Transcription Pathway pathway (Reactome ID: R-HSA-212436). These compounds target 255 genes within this pathway.

What genes are in the Generic Transcription Pathway pathway?

The Generic Transcription Pathway pathway involves 255 genes. Key genes include: ABL1, ADRM1, AGO2, AKT3, AR, ARNT, ASH2L, ATM, AURKA, AURKB.

Generic Transcription Pathway

REACTOME PATHWAY

Reactome: R-HSA-212436255 genes802 compounds

The Generic Transcription Pathway pathway (Reactome ID: R-HSA-212436) involves 255 genes and is affected by 802 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AGO2 AKT3 AR ARNT ASH2L ATM AURKA AURKB BARD1 BCL2L11 BIRC5 BLK BLM BRCA1 BRD2 CAMK2B CAMK2D CARM1 CASP1 CASP2 CBFB CCNA1 CCNB1 CCNC CCNE2 CCNT2 CDC7 CDK1+225 more

Compounds Affecting Generic Transcription Pathway

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Daunorubicin	—	298
5	chrysin	—	300
6	Dasatinib	—	299
7	sp600125	—	117
8	Disulfiram	—	297
9	Hexachlorophene	—	300
10	Sorafenib	—	300
11	Progesterone	—	299
12	Rotenone	—	300
13	Niclosamide	—	299
14	kenpaullone	—	8
15	Ursolic Acid	—	300
16	alsterpaullone	—	12
17	Ethidium	—	300
18	vinblastine sulfate	—	81
19	Resveratrol	—	298
20	Celecoxib	—	295
21	Genistein	—	300
22	Kaempferols	—	300
23	Podophyllotoxin	—	14
24	Nocodazole Nocodazole is	—	215
25	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
26	cycloheximide	—	300
27	Methylene Blue	—	200
28	Reserpine	—	297
29	Dactinomycin	—	297
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Colchicine	—	300
34	egcg	—	300
35	Axitinib	—	298
36	Nisoldipine	—	297
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Vorinostat	—	299
39	pictilisib	—	25
40	Ethinyl Estradiol	—	300
41	Clotrimazole	—	296
42	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
43	Camptothecin	—	300
44	Chlorhexidine	—	299
45	Emetine	—	298
46	Crizotinib	—	298
47	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
48	Spironolactone	—	298
49	Dinitrochlorobenzene	—	300
50	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300

About the Generic Transcription Pathway Pathway

The Generic Transcription Pathway pathway is catalogued in Reactome (ID: R-HSA-212436) and involves 255 genes. In the BiohacksAI corpus, 802 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AGO2, AKT3, AR.