HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

Q: What compounds affect the HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand pathway?

360 compounds in the BiohacksAI corpus have documented interactions with genes in the HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand pathway (Reactome ID: R-HSA-3371497). These compounds target 29 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-337149729 genes360 compounds

The HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand pathway (Reactome ID: R-HSA-3371497) involves 29 genes and is affected by 360 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR FKBP4 FKBP5 HSP90AA1 HSP90AB1 HSPA1A HSPA1B HSPA8 NR3C1 NR3C2 PGR PTGES3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B

Compounds Affecting HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Vincristine	—	299
3	Nocodazole Nocodazole is	—	215
4	vinblastine sulfate	—	81
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Vorinostat	—	299
8	Noscapine	—	300
9	Maytansine	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	Quercetin	—	300
12	Dihydrotestosterone	—	300
13	Progesterone	—	299
14	Medroxyprogesterone Acetate	—	299
15	Spironolactone	—	298
16	Prednisolone	—	1,000
17	Corticosterone	—	300
18	Budesonide	—	1,000
19	cycloheximide	—	300
20	Hydrocortisone	—	299
21	Hydrocortisone	—	298
22	Desoxycorticosterone	—	300
23	Canrenone	—	300
24	Hexachlorophene	—	300
25	Clotrimazole	—	296
26	Fludrocortisone	—	299
27	Masoprocol	—	300
28	Ciclopirox	—	88
29	triolimus [Supplementary Concept]	—	33
30	Aldosterone	—	300
31	Everolimus	—	297
32	Miconazole	—	298
33	Idarubicin	—	299
34	Testosterone	—	299
35	Levonorgestrel	—	292
36	Norgestrel	—	300
37	Androstenedione	—	300
38	Ethinyl Estradiol	—	300
39	Testosterone Propionate	—	300
40	Lynestrenol	—	299
41	Methyltestosterone	—	300
42	Prednisone	—	298
43	Danazol	—	298
44	Estrone	—	300
45	Norethindrone	—	300
46	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
47	Ethynodiol Diacetate	—	300
48	Fluoxymesterone	—	278
49	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
50	Dehydroepiandrosterone	—	300

About the HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Pathway

The HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand pathway is catalogued in Reactome (ID: R-HSA-3371497) and involves 29 genes. In the BiohacksAI corpus, 360 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, FKBP4, FKBP5, HSP90AA1, HSP90AB1.