What genes are in the TAK1-dependent IKK and NF-kappa-B activation pathway?

The TAK1-dependent IKK and NF-kappa-B activation pathway involves 16 genes. Key genes include: APP, CHUK, HMGB1, IKBKB, IRAK1, MAP3K7, NFKB1, NFKB2, NFKBIA, NOD1.

TAK1-dependent IKK and NF-kappa-B activation

Q: What compounds affect the TAK1-dependent IKK and NF-kappa-B activation pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the TAK1-dependent IKK and NF-kappa-B activation pathway (Reactome ID: R-HSA-445989). These compounds target 16 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-44598916 genes210 compounds

The TAK1-dependent IKK and NF-kappa-B activation pathway (Reactome ID: R-HSA-445989) involves 16 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP CHUK HMGB1 IKBKB IRAK1 MAP3K7 NFKB1 NFKB2 NFKBIA NOD1 NOD2 RELA RIPK2 S100B TP53 UBE2N

Compounds Affecting TAK1-dependent IKK and NF-kappa-B activation

#	Compound	Targets Hit	Studies
1	Resveratrol	—	298
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Quercetin	—	300
4	Bortezomib	—	300
5	Disulfiram	—	297
6	Trifluridine	—	295
7	Digitoxin	—	300
8	Digoxin	—	299
9	withaferin	—	300
10	Kaempferols	—	300
11	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
12	chicoric acid	—	117
13	Crizotinib	—	298
14	Hexachlorophene	—	300
15	Axitinib	—	298
16	Camptothecin	—	300
17	cycloheximide	—	300
18	Oxyphenbutazone	—	300
19	Podophyllotoxin	—	14
20	Rutin	—	300
21	Withania	—	500
22	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
23	tamarixetin	—	26
24	Ouabain	—	300
25	Sorafenib	—	300
26	Methylene Blue	—	200
27	Cladribine	—	297
28	Methotrexate	—	289
29	plumbagin [Supplementary Concept]	—	300
30	daph	—	2
31	Thioridazine	—	35
32	vinblastine sulfate	—	81
33	Perphenazine	—	297
34	sp600125	—	117
35	Sertraline	—	1,000
36	Adenosine Triphosphate	—	300
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Chlorhexidine	—	299
39	Dasatinib	—	299
40	Tripterygium	—	300
41	egcg	—	300
42	streptonigrin	—	299
43	Anisomycin	—	247
44	Afatinib	—	297
45	alsterpaullone	—	12
46	Ethidium	—	300
47	Ethinyl Estradiol	—	300
48	Azacitidine	—	298
49	Azacitidine	—	300
50	Rotenone	—	300

About the TAK1-dependent IKK and NF-kappa-B activation Pathway

The TAK1-dependent IKK and NF-kappa-B activation pathway is catalogued in Reactome (ID: R-HSA-445989) and involves 16 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, CHUK, HMGB1, IKBKB, IRAK1.