What genes are in the Interleukin-3, Interleukin-5 and GM-CSF signaling pathway?

The Interleukin-3, Interleukin-5 and GM-CSF signaling pathway involves 18 genes. Key genes include: FYN, GRB2, HCK, IL3, INPPL1, JAK2, JAK3, LYN, PIK3CB, PIK3CD.

Interleukin-3, Interleukin-5 and GM-CSF signaling

Q: What compounds affect the Interleukin-3, Interleukin-5 and GM-CSF signaling pathway?

215 compounds in the BiohacksAI corpus have documented interactions with genes in the Interleukin-3, Interleukin-5 and GM-CSF signaling pathway (Reactome ID: R-HSA-512988). These compounds target 18 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-51298818 genes215 compounds

The Interleukin-3, Interleukin-5 and GM-CSF signaling pathway (Reactome ID: R-HSA-512988) involves 18 genes and is affected by 215 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN GRB2 HCK IL3 INPPL1 JAK2 JAK3 LYN PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACA PTPN6 STAT5A SYK YES1

Compounds Affecting Interleukin-3, Interleukin-5 and GM-CSF signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	Crizotinib	—	298
4	pictilisib	—	25
5	tyrphostin ag 1478	—	4
6	ly294002	—	11
7	Sirolimus	—	300
8	alpelisib	—	227
9	sp600125	—	117
10	torin 1	—	10
11	Axitinib	—	298
12	Afatinib	—	297
13	Cladribine	—	297
14	Quercetin	—	300
15	kenpaullone	—	8
16	Wortmannin	—	300
17	Methotrexate	—	289
18	Podophyllotoxin	—	14
19	Trifluridine	—	295
20	Azathioprine	—	300
21	Tripterygium	—	300
22	Methylene Blue	—	200
23	2-Methoxyestradiol	—	300
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Calcitriol	—	300
26	Camptothecin	—	300
27	celastrol	—	300
28	Vemurafenib	—	298
29	Kaempferols	—	300
30	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
31	alsterpaullone	—	12
32	Cytarabine	—	297
33	Ku 0063794 [Supplementary Concept]	—	7
34	Ouabain	—	300
35	Atorvastatin	—	1,000
36	Simvastatin	—	1,000
37	Chlorhexidine	—	299
38	Clofarabine	—	298
39	Colchicine	—	300
40	cycloheximide	—	300
41	deguelin [Supplementary Concept]	—	151
42	Digoxin	—	299
43	Disulfiram	—	297
44	Emetine	—	298
45	Ezetimibe	—	296
46	Lovastatin	—	300
47	Medroxyprogesterone Acetate	—	299
48	Melphalan	—	300
49	Mometasone Furoate	—	292
50	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300

About the Interleukin-3, Interleukin-5 and GM-CSF signaling Pathway

The Interleukin-3, Interleukin-5 and GM-CSF signaling pathway is catalogued in Reactome (ID: R-HSA-512988) and involves 18 genes. In the BiohacksAI corpus, 215 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRB2, HCK, IL3, INPPL1.