What compounds affect the Regulated Necrosis pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulated Necrosis pathway (Reactome ID: R-HSA-5218859). These compounds target 12 genes within this pathway.

What genes are in the Regulated Necrosis pathway?

The Regulated Necrosis pathway involves 12 genes. Key genes include: CASP1, CASP4, CASP5, CDC37, ELANE, GSDMD, HMGB1, HSP90AA1, IL1B, PRKN.

Regulated Necrosis

REACTOME PATHWAY

Reactome: R-HSA-521885912 genes210 compounds

The Regulated Necrosis pathway (Reactome ID: R-HSA-5218859) involves 12 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 CASP4 CASP5 CDC37 ELANE GSDMD HMGB1 HSP90AA1 IL1B PRKN RIPK3 TP53

Compounds Affecting Regulated Necrosis

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Hexachlorophene	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	cycloheximide	—	300
5	celastrol	—	300
6	Ethidium	—	300
7	Ethinyl Estradiol	—	300
8	Bortezomib	—	300
9	Niclosamide	—	299
10	Methotrexate	—	289
11	Quercetin	—	300
12	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
13	Genistein	—	300
14	Ciclopirox	—	88
15	Dinitrochlorobenzene	—	300
16	Clotrimazole	—	296
17	Spironolactone	—	298
18	Thioridazine	—	35
19	Carbazilquinone	—	48
20	Digitoxin	—	300
21	Digoxin	—	299
22	Harmaline	—	300
23	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
24	Idarubicin	—	299
25	Nisoldipine	—	297
26	Oxyphenbutazone	—	300
27	sp600125	—	117
28	triolimus [Supplementary Concept]	—	33
29	triflupromazine hydrochloride	—	12
30	2-Chloroadenosine 2-Chloroadenosine.	—	300
31	Astemizole Antihistamine drug now withdrawn from	—	280
32	Bisphenol A-Glycidyl Methacrylate	—	197
33	Chlorhexidine	—	299
34	monorden	—	8
35	tyrphostin 9	—	2
36	kenpaullone	—	8
37	Masoprocol	—	300
38	Wortmannin	—	300
39	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
40	felbinac	—	31
41	Azacitidine	—	298
42	Azacitidine	—	300
43	Methylene Blue	—	200
44	Rotenone	—	300
45	Azathioprine	—	300
46	Cladribine	—	297
47	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
48	Cytarabine	—	297
49	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
50	Melphalan	—	300

About the Regulated Necrosis Pathway

The Regulated Necrosis pathway is catalogued in Reactome (ID: R-HSA-5218859) and involves 12 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, CASP4, CASP5, CDC37, ELANE.