What compounds affect the Regulation of TP53 Activity pathway?

251 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of TP53 Activity pathway (Reactome ID: R-HSA-5633007). These compounds target 57 genes within this pathway.

What genes are in the Regulation of TP53 Activity pathway?

The Regulation of TP53 Activity pathway involves 57 genes. Key genes include: AKT3, ATM, AURKA, AURKB, BARD1, BLM, BRCA1, CCNA1, CDK1, CDK2.

Regulation of TP53 Activity

REACTOME PATHWAY

Reactome: R-HSA-563300757 genes251 compounds

The Regulation of TP53 Activity pathway (Reactome ID: R-HSA-5633007) involves 57 genes and is affected by 251 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 ATM AURKA AURKB BARD1 BLM BRCA1 CCNA1 CDK1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CSNK2A1 CSNK2A2 CSNK2B DNA2 DYRK2 EHMT1 EHMT2 EP300 HDAC1 HDAC2 HIPK1 HIPK2 KMT5A L3MBTL1 MAPK11 MAPK14+27 more

Compounds Affecting Regulation of TP53 Activity

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Niclosamide	—	299
3	Ursolic Acid	—	300
4	Quercetin	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	kenpaullone	—	8
7	Rotenone	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Antimycin	—	300
11	Sorafenib	—	300
12	fisetin	—	78
13	alsterpaullone	—	12
14	chrysin	—	300
15	pictilisib	—	25
16	egcg	—	300
17	Adenosine Monophosphate Adenine nucleotide containing	—	300
18	Proguanil	—	299
19	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
20	Berberine	—	300
21	Oleanolic Acid	—	300
22	Metformin	—	1,000
23	rafoxanide	—	172
24	ly294002	—	11
25	Kaempferols	—	300
26	Hexachlorophene	—	300
27	Azacitidine	—	298
28	Azacitidine	—	300
29	Methylene Blue	—	200
30	Cytarabine	—	297
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Melphalan	—	300
33	Methotrexate	—	289
34	Disulfiram	—	297
35	Trifluridine	—	295
36	Ciclopirox	—	88
37	cycloheximide	—	300
38	Vorinostat	—	299
39	vinblastine sulfate	—	81
40	Nocodazole Nocodazole is	—	215
41	Astemizole Antihistamine drug now withdrawn from	—	280
42	Chlorhexidine	—	299
43	Colchicine	—	300
44	Demecolcine	—	246
45	Ku 0063794 [Supplementary Concept]	—	7
46	Calcimycin	—	216
47	streptonigrin	—	299
48	Daunorubicin	—	298
49	Axitinib	—	298
50	Camptothecin	—	300

About the Regulation of TP53 Activity Pathway

The Regulation of TP53 Activity pathway is catalogued in Reactome (ID: R-HSA-5633007) and involves 57 genes. In the BiohacksAI corpus, 251 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, ATM, AURKA, AURKB, BARD1.