What compounds affect the Infectious disease pathway?

623 compounds in the BiohacksAI corpus have documented interactions with genes in the Infectious disease pathway (Reactome ID: R-HSA-5663205). These compounds target 246 genes within this pathway.

What genes are in the Infectious disease pathway?

The Infectious disease pathway involves 246 genes. Key genes include: ABL1, ADAM17, ADCY9, ADORA2B, ADRM1, AKT3, APOBEC3G, APP, ATP1A1, ATP1A2.

Infectious disease

REACTOME PATHWAY

Reactome: R-HSA-5663205246 genes623 compounds

The Infectious disease pathway (Reactome ID: R-HSA-5663205) involves 246 genes and is affected by 623 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADAM17 ADCY9 ADORA2B ADRM1 AKT3 APOBEC3G APP ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 AXL BCL2L1 BRD4 BTK CAMK2B CAMK2D CASP1 CASP4 CBX1 CCNC CCNT2 CDC42 CDK19 CDK7 CDK8+216 more

Compounds Affecting Infectious disease

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Sorafenib	—	300
4	Crizotinib	—	298
5	Podophyllotoxin	—	14
6	Nocodazole Nocodazole is	—	215
7	sp600125	—	117
8	Colchicine	—	300
9	vinblastine sulfate	—	81
10	Disulfiram	—	297
11	Vorinostat	—	299
12	Dasatinib	—	299
13	Axitinib	—	298
14	Vincristine	—	299
15	Digitoxin	—	300
16	alsterpaullone	—	12
17	kenpaullone	—	8
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Digoxin	—	299
20	Hexachlorophene	—	300
21	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
22	Reserpine	—	297
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	Ouabain	—	300
25	Demecolcine	—	246
26	egcg	—	300
27	tyrphostin ag 1478	—	4
28	Noscapine	—	300
29	Kaempferols	—	300
30	Maytansine	—	300
31	Daunorubicin	—	298
32	cycloheximide	—	300
33	ly294002	—	11
34	Camptothecin	—	300
35	chrysin	—	300
36	Afatinib	—	297
37	pictilisib	—	25
38	Idarubicin	—	299
39	Ethidium	—	300
40	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
41	Genistein	—	300
42	Methylene Blue	—	200
43	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
44	Nisoldipine	—	297
45	Masoprocol	—	300
46	Calcimycin	—	216
47	Resveratrol	—	298
48	Niclosamide	—	299
49	Clotrimazole	—	296
50	Lovastatin	—	300

About the Infectious disease Pathway

The Infectious disease pathway is catalogued in Reactome (ID: R-HSA-5663205) and involves 246 genes. In the BiohacksAI corpus, 623 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADAM17, ADCY9, ADORA2B, ADRM1.