What compounds affect the DNA Double-Strand Break Repair pathway?

335 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Double-Strand Break Repair pathway (Reactome ID: R-HSA-5693532). These compounds target 35 genes within this pathway.

What genes are in the DNA Double-Strand Break Repair pathway?

The DNA Double-Strand Break Repair pathway involves 35 genes. Key genes include: ABL1, ATM, BAP1, BARD1, BLM, BRCA1, CCNA1, CDK2, CHEK1, CHEK2.

DNA Double-Strand Break Repair

REACTOME PATHWAY

Reactome: R-HSA-569353235 genes335 compounds

The DNA Double-Strand Break Repair pathway (Reactome ID: R-HSA-5693532) involves 35 genes and is affected by 335 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ATM BAP1 BARD1 BLM BRCA1 CCNA1 CDK2 CHEK1 CHEK2 DNA2 EYA2 FEN1 KDM4A KDM4B MAPK8 MUS81 NSD2 PARP1 PCNA POLH POLK POLL PPP5C PRKDC RAD51 RAD52 RBBP8 SEM1 SIRT6+5 more

Compounds Affecting DNA Double-Strand Break Repair

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Quercetin	—	300
3	Ethidium	—	300
4	sp600125	—	117
5	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
6	Aurintricarboxylic Acid	—	184
7	Methylene Blue	—	200
8	Chlorhexidine	—	299
9	Nocodazole Nocodazole is	—	215
10	Hexachlorophene	—	300
11	Idarubicin	—	299
12	kenpaullone	—	8
13	Oxytetracycline	—	300
14	Methotrexate	—	289
15	Daunorubicin	—	298
16	alsterpaullone	—	12
17	Astemizole Antihistamine drug now withdrawn from	—	280
18	Demecolcine	—	246
19	piceatannol	—	300
20	Levodopa	—	297
21	streptonigrin	—	299
22	Axitinib	—	298
23	Bortezomib	—	300
24	Colchicine	—	300
25	cycloheximide	—	300
26	Melphalan	—	300
27	Podophyllotoxin	—	14
28	Trifluridine	—	295
29	vinblastine sulfate	—	81
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Azacitidine	—	298
32	Azacitidine	—	300
33	Ciclopirox	—	88
34	Cytarabine	—	297
35	Niclosamide	—	299
36	Perphenazine	—	297
37	triolimus [Supplementary Concept]	—	33
38	Resveratrol	—	298
39	rafoxanide	—	172
40	alpha-Linolenic Acid	—	300
41	Diiodotyrosine	—	300
42	Norepinephrine Precursor of epinephrine that is secreted by	—	298
43	Calcimycin	—	216
44	Dasatinib	—	299
45	Clofarabine	—	298
46	Thapsigargin	—	300
47	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
48	Doxycycline	—	999
49	Sertraline	—	1,000
50	Camptothecin	—	300

About the DNA Double-Strand Break Repair Pathway

The DNA Double-Strand Break Repair pathway is catalogued in Reactome (ID: R-HSA-5693532) and involves 35 genes. In the BiohacksAI corpus, 335 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ATM, BAP1, BARD1, BLM.