What compounds affect the Homology Directed Repair pathway?

261 compounds in the BiohacksAI corpus have documented interactions with genes in the Homology Directed Repair pathway (Reactome ID: R-HSA-5693538). These compounds target 23 genes within this pathway.

What genes are in the Homology Directed Repair pathway?

The Homology Directed Repair pathway involves 23 genes. Key genes include: ABL1, ATM, BARD1, BLM, BRCA1, CCNA1, CDK2, CHEK1, DNA2, FEN1.

Homology Directed Repair

REACTOME PATHWAY

Reactome: R-HSA-569353823 genes261 compounds

The Homology Directed Repair pathway (Reactome ID: R-HSA-5693538) involves 23 genes and is affected by 261 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ATM BARD1 BLM BRCA1 CCNA1 CDK2 CHEK1 DNA2 FEN1 MUS81 NSD2 PARP1 PCNA POLH POLK RAD51 RAD52 RBBP8 SEM1 SIRT6 UBE2N WRN

Compounds Affecting Homology Directed Repair

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Quercetin	—	300
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Aurintricarboxylic Acid	—	184
5	Methylene Blue	—	200
6	Chlorhexidine	—	299
7	Ethidium	—	300
8	Nocodazole Nocodazole is	—	215
9	Idarubicin	—	299
10	kenpaullone	—	8
11	Levodopa	—	297
12	Oxytetracycline	—	300
13	streptonigrin	—	299
14	Methotrexate	—	289
15	Podophyllotoxin	—	14
16	sp600125	—	117
17	Daunorubicin	—	298
18	alsterpaullone	—	12
19	Astemizole Antihistamine drug now withdrawn from	—	280
20	Demecolcine	—	246
21	Hexachlorophene	—	300
22	piceatannol	—	300
23	Norepinephrine Precursor of epinephrine that is secreted by	—	298
24	Bortezomib	—	300
25	Colchicine	—	300
26	cycloheximide	—	300
27	Melphalan	—	300
28	Trifluridine	—	295
29	vinblastine sulfate	—	81
30	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
31	Azacitidine	—	298
32	Azacitidine	—	300
33	Ciclopirox	—	88
34	Cytarabine	—	297
35	Fluspirilene	—	74
36	Imatinib Mesylate	—	300
37	lidoflazine	—	278
38	Niclosamide	—	299
39	Perphenazine	—	297
40	alpha-Linolenic Acid	—	300
41	Masoprocol	—	300
42	Diiodotyrosine	—	300
43	Methyldopa	—	297
44	Resveratrol	—	298
45	rafoxanide	—	172
46	Dasatinib	—	299
47	Axitinib	—	298
48	Crizotinib	—	298
49	ag490	—	14
50	alpelisib	—	227

About the Homology Directed Repair Pathway

The Homology Directed Repair pathway is catalogued in Reactome (ID: R-HSA-5693538) and involves 23 genes. In the BiohacksAI corpus, 261 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ATM, BARD1, BLM, BRCA1.