What genes are in the Regulation of TP53 Expression and Degradation pathway?

The Regulation of TP53 Expression and Degradation pathway involves 17 genes. Key genes include: AKT3, ATM, CCNA1, CDK1, CDK2, CHEK2, MAPKAP1, MDM2, MDM4, MLST8.

Regulation of TP53 Expression and Degradation

Q: What compounds affect the Regulation of TP53 Expression and Degradation pathway?

194 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of TP53 Expression and Degradation pathway (Reactome ID: R-HSA-6806003). These compounds target 17 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-680600317 genes194 compounds

The Regulation of TP53 Expression and Degradation pathway (Reactome ID: R-HSA-6806003) involves 17 genes and is affected by 194 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 ATM CCNA1 CDK1 CDK2 CHEK2 MAPKAP1 MDM2 MDM4 MLST8 MTOR PDPK1 PPP2CA RICTOR SGK1 TP53 USP7

Compounds Affecting Regulation of TP53 Expression and Degradation

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Ku 0063794 [Supplementary Concept]	—	7
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Methylene Blue	—	200
6	Niclosamide	—	299
7	Sertraline	—	1,000
8	tyrphostin 9	—	2
9	torin 1	—	10
10	Hexachlorophene	—	300
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Rotenone	—	300
14	Cladribine	—	297
15	Cytarabine	—	297
16	Melphalan	—	300
17	Methotrexate	—	289
18	Trifluridine	—	295
19	Quercetin	—	300
20	Ciclopirox	—	88
21	cycloheximide	—	300
22	Dinitrochlorobenzene	—	300
23	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
24	Vorinostat	—	299
25	Spironolactone	—	298
26	Thioridazine	—	35
27	vinblastine sulfate	—	81
28	Digoxin	—	299
29	Nisoldipine	—	297
30	Nocodazole Nocodazole is	—	215
31	Oxyphenbutazone	—	300
32	rafoxanide	—	172
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Chlorhexidine	—	299
35	Colchicine	—	300
36	Demecolcine	—	246
37	Calcimycin	—	216
38	streptonigrin	—	299
39	Ursolic Acid	—	300
40	Lovastatin	—	300
41	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
42	Disulfiram	—	297
43	Camptothecin	—	300
44	Resveratrol	—	298
45	Clotrimazole	—	296
46	chrysin	—	300
47	celastrol	—	300
48	Clofibrate	—	299
49	Fenofibrate	—	297
50	Idarubicin	—	299

About the Regulation of TP53 Expression and Degradation Pathway

The Regulation of TP53 Expression and Degradation pathway is catalogued in Reactome (ID: R-HSA-6806003) and involves 17 genes. In the BiohacksAI corpus, 194 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, ATM, CCNA1, CDK1, CDK2.