What compounds affect the PTEN Regulation pathway?

284 compounds in the BiohacksAI corpus have documented interactions with genes in the PTEN Regulation pathway (Reactome ID: R-HSA-6807070). These compounds target 59 genes within this pathway.

What genes are in the PTEN Regulation pathway?

The PTEN Regulation pathway involves 59 genes. Key genes include: ADRM1, AGO2, AKT3, CSNK2A1, CSNK2A2, CSNK2B, EED, EZH2, FRK, HDAC1.

PTEN Regulation

REACTOME PATHWAY

Reactome: R-HSA-680707059 genes284 compounds

The PTEN Regulation pathway (Reactome ID: R-HSA-6807070) involves 59 genes and is affected by 284 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 AKT3 CSNK2A1 CSNK2A2 CSNK2B EED EZH2 FRK HDAC1 HDAC2 HDAC3 HDAC5 HDAC7 JUN KDM1A MAPK1 MAPK3 MLST8 MTOR NR2E1 OTUD3 PPARG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7+29 more

Compounds Affecting PTEN Regulation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	Daunorubicin	—	298
8	Camptothecin	—	300
9	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
10	pictilisib	—	25
11	Vorinostat	—	299
12	chrysin	—	300
13	Ursolic Acid	—	300
14	Disulfiram	—	297
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	scriptaid	—	53
17	Valproic Acid	—	296
18	Butyric Acid	—	300
19	Celecoxib	—	295
20	Rotenone	—	300
21	Clotrimazole	—	296
22	sp600125	—	117
23	alpha-Linolenic Acid	—	300
24	Ku 0063794 [Supplementary Concept]	—	7
25	Maprotiline	—	299
26	Kaempferols	—	300
27	ly294002	—	11
28	fisetin	—	78
29	Sorafenib	—	300
30	Methylene Blue	—	200
31	plumbagin [Supplementary Concept]	—	300
32	Genistein	—	300
33	Loratadine	—	296
34	Thioridazine	—	35
35	vinblastine sulfate	—	81
36	Fenofibrate	—	297
37	Nocodazole Nocodazole is	—	215
38	pd98059	—	7
39	triflupromazine hydrochloride	—	12
40	Astemizole Antihistamine drug now withdrawn from	—	280
41	Dasatinib	—	299
42	withaferin	—	300
43	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
44	egcg	—	300
45	Sirolimus	—	300
46	torin 1	—	10
47	Everolimus	—	297
48	alsterpaullone	—	12
49	kenpaullone	—	8
50	Vanillic Acid	—	300

About the PTEN Regulation Pathway

The PTEN Regulation pathway is catalogued in Reactome (ID: R-HSA-6807070) and involves 59 genes. In the BiohacksAI corpus, 284 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, AKT3, CSNK2A1, CSNK2A2.