What compounds affect the G2/M Transition pathway?

209 compounds in the BiohacksAI corpus have documented interactions with genes in the G2/M Transition pathway (Reactome ID: R-HSA-69275). These compounds target 80 genes within this pathway.

What genes are in the G2/M Transition pathway?

The G2/M Transition pathway involves 80 genes. Key genes include: ADRM1, AURKA, CCNA1, CCNB1, CCNB2, CDC25A, CDC25B, CDK1, CDK11A, CDK11B.

G2/M Transition

REACTOME PATHWAY

Reactome: R-HSA-6927580 genes209 compounds

The G2/M Transition pathway (Reactome ID: R-HSA-69275) involves 80 genes and is affected by 209 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AURKA CCNA1 CCNB1 CCNB2 CDC25A CDC25B CDK1 CDK11A CDK11B CDK2 CDK7 CSNK1D CSNK1E CUL1 EP300 FOXM1 HSP90AA1 HSP90AB1 NEK2 PKMYT1 PLK1 PLK4 PPME1 PPP2CA PRKACA PSMA1 PSMA2 PSMA3 PSMA4+50 more

Compounds Affecting G2/M Transition

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Noscapine	—	300
5	Vincristine	—	299
6	Vorinostat	—	299
7	vinblastine sulfate	—	81
8	Demecolcine	—	246
9	Reserpine	—	297
10	Podophyllotoxin	—	14
11	Maytansine	—	300
12	sp600125	—	117
13	Quercetin	—	300
14	kenpaullone	—	8
15	alsterpaullone	—	12
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	plumbagin [Supplementary Concept]	—	300
18	chrysin	—	300
19	indirubin	—	300
20	Hexachlorophene	—	300
21	Disulfiram	—	297
22	Idarubicin	—	299
23	Dasatinib	—	299
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
26	Sorafenib	—	300
27	Crizotinib	—	298
28	pictilisib	—	25
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	Vitamin K 3	—	300
31	Axitinib	—	298
32	ninhydrin	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Clotrimazole	—	296
35	celastrol	—	300
36	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
37	triolimus [Supplementary Concept]	—	33
38	monorden	—	8
39	Masoprocol	—	300
40	fisetin	—	78
41	egcg	—	300
42	Rotenone	—	300
43	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
44	Genistein	—	300
45	Ciclopirox	—	88
46	cycloheximide	—	300
47	Troglitazone	—	299
48	Clofibrate	—	299
49	Fenofibrate	—	297
50	Harmaline	—	300

About the G2/M Transition Pathway

The G2/M Transition pathway is catalogued in Reactome (ID: R-HSA-69275) and involves 80 genes. In the BiohacksAI corpus, 209 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AURKA, CCNA1, CCNB1, CCNB2.