What compounds affect the Cell Cycle, Mitotic pathway?

289 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell Cycle, Mitotic pathway (Reactome ID: R-HSA-69278). These compounds target 123 genes within this pathway.

What genes are in the Cell Cycle, Mitotic pathway?

The Cell Cycle, Mitotic pathway involves 123 genes. Key genes include: ABL1, ADRM1, AKT3, AURKA, AURKB, BIRC5, CCNA1, CCNB1, CCNB2, CCNE2.

Cell Cycle, Mitotic

REACTOME PATHWAY

Reactome: R-HSA-69278123 genes289 compounds

The Cell Cycle, Mitotic pathway (Reactome ID: R-HSA-69278) involves 123 genes and is affected by 289 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AKT3 AURKA AURKB BIRC5 CCNA1 CCNB1 CCNB2 CCNE2 CDC25A CDC25B CDC7 CDK1 CDK11A CDK11B CDK2 CDK4 CDK6 CDK7 CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B CUL1 DHFR DNA2 EML4 EP300+93 more

Compounds Affecting Cell Cycle, Mitotic

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Nocodazole Nocodazole is	—	215
3	Colchicine	—	300
4	Vorinostat	—	299
5	Reserpine	—	297
6	Vincristine	—	299
7	kenpaullone	—	8
8	Quercetin	—	300
9	Noscapine	—	300
10	Podophyllotoxin	—	14
11	vinblastine sulfate	—	81
12	sp600125	—	117
13	Demecolcine	—	246
14	alsterpaullone	—	12
15	Maytansine	—	300
16	Sorafenib	—	300
17	Dasatinib	—	299
18	Crizotinib	—	298
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
21	fisetin	—	78
22	chrysin	—	300
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	indirubin	—	300
25	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
26	plumbagin [Supplementary Concept]	—	300
27	pictilisib	—	25
28	Hexachlorophene	—	300
29	Axitinib	—	298
30	Idarubicin	—	299
31	Disulfiram	—	297
32	Clotrimazole	—	296
33	triolimus [Supplementary Concept]	—	33
34	Kaempferols	—	300
35	ly294002	—	11
36	egcg	—	300
37	Daunorubicin	—	298
38	Vitamin K 3	—	300
39	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
40	Camptothecin	—	300
41	Genistein	—	300
42	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
43	monorden	—	8
44	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
45	Masoprocol	—	300
46	Oxytetracycline	—	300
47	tyrphostin ag 1478	—	4
48	hydroxyfasudil [Supplementary Concept]	—	11
49	Ethidium	—	300
50	Methylene Blue	—	200

About the Cell Cycle, Mitotic Pathway

The Cell Cycle, Mitotic pathway is catalogued in Reactome (ID: R-HSA-69278) and involves 123 genes. In the BiohacksAI corpus, 289 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AKT3, AURKA, AURKB.