What compounds affect the Gene expression (Transcription) pathway?

817 compounds in the BiohacksAI corpus have documented interactions with genes in the Gene expression (Transcription) pathway (Reactome ID: R-HSA-74160). These compounds target 277 genes within this pathway.

What genes are in the Gene expression (Transcription) pathway?

The Gene expression (Transcription) pathway involves 277 genes. Key genes include: ABL1, ADRM1, AGO2, AKT3, AR, ARNT, ASH2L, ATM, AURKA, AURKB.

Gene expression (Transcription)

REACTOME PATHWAY

Reactome: R-HSA-74160277 genes817 compounds

The Gene expression (Transcription) pathway (Reactome ID: R-HSA-74160) involves 277 genes and is affected by 817 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADRM1 AGO2 AKT3 AR ARNT ASH2L ATM AURKA AURKB BARD1 BCL2L11 BIRC5 BLK BLM BRCA1 BRD2 CAMK2B CAMK2D CARM1 CASP1 CASP2 CBFB CCNA1 CCNB1 CCNC CCNE2 CCNT2 CDC7 CDK1+247 more

Compounds Affecting Gene expression (Transcription)

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Daunorubicin	—	298
5	Disulfiram	—	297
6	chrysin	—	300
7	Ethidium	—	300
8	Dasatinib	—	299
9	sp600125	—	117
10	Hexachlorophene	—	300
11	Methylene Blue	—	200
12	Sorafenib	—	300
13	alsterpaullone	—	12
14	Progesterone	—	299
15	Rotenone	—	300
16	Niclosamide	—	299
17	kenpaullone	—	8
18	Ursolic Acid	—	300
19	cycloheximide	—	300
20	vinblastine sulfate	—	81
21	Azacitidine	—	298
22	Azacitidine	—	300
23	Resveratrol	—	298
24	Celecoxib	—	295
25	Genistein	—	300
26	Kaempferols	—	300
27	Reserpine	—	297
28	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
29	Podophyllotoxin	—	14
30	Nocodazole Nocodazole is	—	215
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Dactinomycin	—	297
34	egcg	—	300
35	Nisoldipine	—	297
36	Colchicine	—	300
37	Axitinib	—	298
38	Chlorhexidine	—	299
39	Clotrimazole	—	296
40	Astemizole Antihistamine drug now withdrawn from	—	280
41	Vorinostat	—	299
42	pictilisib	—	25
43	Ethinyl Estradiol	—	300
44	Camptothecin	—	300
45	s adenosylhomocysteine	—	300
46	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
47	Emetine	—	298
48	Fluspirilene	—	74
49	Crizotinib	—	298
50	trichostatic acid [Supplementary Concept] related to trichostatin	—	300

About the Gene expression (Transcription) Pathway

The Gene expression (Transcription) pathway is catalogued in Reactome (ID: R-HSA-74160) and involves 277 genes. In the BiohacksAI corpus, 817 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADRM1, AGO2, AKT3, AR.